By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Polyethylene Glycols are discussed in a new report. According to news originating from Hamadan, Iran, by NewsRx correspondents, research stated, "In this work a new synthetic hydrogel was applied to the synthesis of gold nanoparticles (GNPs). Poly(styrene-alt-maleic acid) pH-sensitive hydrogel, bearing negatively charged -COO- groups, was used for this purpose."
Our news journalists obtained a quote from the research from Bu Ali Sina University, "There was no need for the additional reducing agent and surfactant for the synthesis of GNPs. The optimum conditions for synthesis of the GNPs were obtained by studying the effects of pH and concentration of hydrogel. The structure, size and morphology of the synthesized GNPs were investigated by UV-vis spectra and transmission electron micrograph (TEM), respectively. In addition, the interactions between synthesized GNPs with several drugs such as acetaminophen (ACET), ascorbic acid (AA) and folic acid (FA) were studied. The results showed that the synthesized GNPs can be used as a new and highly efficient spectrophotometric sensor for the selective recognition and monitoring of three drugs in real samples such as serum samples. The sensitivity and selectivity of GNPs toward other drugs as potential interferents were also studied. The linear ranges for the spectrophotometric determination of ACET, AA and FA were calculated as well. Limit of detection (calculated as 3 times of standard deviation of blank) were obtained as 1.8 x 10(-6) M, 2.7 x 10(-7) M, 2 x 10(-6) M for ACET, AA and FA, respectively."
According to the news editors, the research concluded: "The proposed method was successfully used to the determination of ACET, M and FA in various serum samples."
For more information on this research see: Synthesis of gold nanoparticles using pH-sensitive hydrogel and its application for colorimetric determination of acetaminophen, ascorbic acid and folic acid. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 2014;441():517-524. Colloids and Surfaces A-Physicochemical and Engineering Aspects can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Polyethylene Glycols).
The news correspondents report that additional information may be obtained from M. Bahram, Bu Ali Sina Univ, Fac Chem, Dept. of Analyt Chem, Hamadan, Iran. Additional authors for this research include F. Hoseinzadeh, K. Farhadi, M. Saadat, P. Najafi-Moghaddam and A. Afkhami.
Keywords for this news article include: Iran, Asia, Pharmaceuticals, Drugs, Hamadan, Therapy, Alcohols, Hydrogel, Sugar Acids, Acetanilides, Acetaminophen, Ascorbic Acid, Nanotechnology, Organic Chemicals, Gold Nanoparticles, Polyethylene Glycols, Emerging Technologies
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