News Column

Researchers from University of Pennsylvania Detail New Studies and Findings in the Area of Lymphoid Tissue

February 7, 2014



By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Lymphoid Tissue. According to news reporting originating from Philadelphia, Pennsylvania, by NewsRx correspondents, research stated, "Nanoparticulate drug delivery systems are one of the most widely investigated approaches for developing novel therapies for a variety of diseases. However, rapid clearance and poor targeting limit their clinical utility."

Our news editors obtained a quote from the research from the University of Pennsylvania, "Here, we describe an approach to harness the flexibility, circulation, and vascular mobility of red blood cells (RBCs) to simultaneously overcome these limitations (cellular hitchhiking). A noncovalent attachment of nanoparticles to RBCs simultaneously increases their level in blood over a 24 h period and allows transient accumulation in the lungs, while reducing their uptake by liver and spleen. RBC-adsorbed nanoparticles exhibited similar to 3-fold increase in blood persistence and similar to 7-fold higher accumulation in lungs. RBC-adsorbed nanoparticles improved lung/liver and lung/spleen nanoparticle accumulation by over 15-fold and 10-fold, respectively. Accumulation in lungs is attributed to mechanical transfer of particles from the RBC surface to lung endothelium. Independent tracing of both nanoparticles and RBCs in vivo confirmed that RBCs themselves do not accumulate in lungs."

According to the news editors, the research concluded: "Attachment of anti-ICAM-1 antibody to the exposed surface of NPs that were attached to RBCs led to further increase in lung targeting and retention over 24 h. Cellular hitchhiking onto RBCs provides a new platform for improving the blood pharmacokinetics and vascular delivery of nanoparticles while simultaneously avoiding uptake by liver and spleen, thus opening the door for new applications."

For more information on this research see: Delivering Nanoparticles to Lungs while Avoiding Liver and Spleen through Adsorption on Red Blood Cells. ACS Nano, 2013;7(12):11129-11137. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)

The news editors report that additional information may be obtained by contacting A.C. Anselmo, University of Pennsylvania, Center Translat Targeted Therapeut & Nanomed, Perelman Sch Med, Philadelphia, PA 19104, United States. Additional authors for this research include V. Gupta, B.J. Zern, D. Pan, M. Zakrewsky, V. Muzykantov and S. Mitragotri (see also Lymphoid Tissue).

Keywords for this news article include: Spleen, Blood Cells, Philadelphia, Pennsylvania, Nanoparticle, United States, Nanotechnology, Lymphoid Tissue, Emerging Technologies, Hemic and Immune Systems, North and Central America

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Source: Health & Medicine Week


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