News Column

Researchers at University of Karachi Report New Data on Leukemia

February 3, 2014



By a News Reporter-Staff News Editor at Hematology Week -- Data detailed on Leukemia have been presented. According to news reporting out of Karachi, Pakistan, by NewsRx editors, research stated, "Polymers either serve as shielding or capping agents to restrict the nanoparticle size. This study demonstrates the polymer depositions and their effects in synthesis and sharp stabilization of gold nanoparticles (AuNPs) and to develop gold/silver nanoalloys (Au/Ag nanoalloys)."

Our news journalists obtained a quote from the research from the University of Karachi, "Effects of different polymers are tested to justify their role in synthesis and stability of phloroglucinol (PG) coated AuNPs and Au/Ag nanoalloys. Cationic and anionic i.e. [Polydiallyldimethylammonium](+) (PDDA), [Polyethyleneimine](+) (PEI), [Polystyrene sulfonate](2-) (PSS) and neutral polymer Polychlorotriflouroethylene (PCTFE) produce praiseworthy stable AuNPs and Au/Ag nanoalloy. To prove polymer effects characterization protocols including UV-vis, Fluorescence (PL), IR and AFM imaging are performed to fully investigate the mechanism and size characteristics of these nanoparticles/nanoalloys. In this study sharp size controlling/sheilding effects were observed particularly with cationic polymers simply through the favorable electrostatic interactions with the terminal ends of PG Potent/significant detection of doxorubicin (DOX, an antileukemic agent) via fluorescence resonance energy transfer (FRET) between PEI shielded AuNPs (AuNPEI) and DOX was achieved upto 10 pM level, while PDDA protected AuNPs facilitated the detection of ascorbic acid based on fluorescence enhancement effects in wide range (10-200 nM) and with detection limit of 200 pM. Similarly sensing performance of PEI stabilized Au/Ag nanoalloys on addition of halides (Cl(-), Br(-), I(-)) is evaluated through red shifted SPR along with continuous increase in absorbance and also through AFM."

According to the news editors, the research concluded: "Moreover the addition of halide ions also helped the regeneration of AuNPs by taking away silver from the Au/Ag nanoalloys enabling their detections upto subnanomolar levels."

For more information on this research see: Polymers effects on synthesis of AuNPs, and Au/Ag nanoalloys: indirectly generated AuNPs and versatile sensing applications including anti-leukemic agent. Biosensors & Bioelectronics, 2014;53():51-7. (Elsevier - www.elsevier.com; Biosensors & Bioelectronics - www.elsevier.com/wps/product/cws_home/405913)

Our news journalists report that additional information may be obtained by contacting S. Jahan, ICCBS, HEJ Research Institute of Chemistry, University of Karachi, 75270 Karachi, Pakistan. Additional authors for this research include F. Mansoor and S. Kanwal (see also Leukemia).

Keywords for this news article include: Asia, Karachi, Pakistan, Leukemia, Nanoparticle, Nanotechnology, Emerging Technologies.

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Source: Hematology Week


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