By a News Reporter-Staff News Editor at Information Technology Newsweekly -- Investigators publish new report on DNA Research. According to news reporting out of London, United Kingdom, by VerticalNews editors, research stated, "DNA methylation is indispensible for normal human genome function. Currently there is an increasingly large number of DNA methylomic data being released in the public domain allowing for an opportunity to investigate the relationships between the DNA methylome, genome function, and human phenotypes."
Our news journalists obtained a quote from the research from Queen Mary University, "The Illumina450K is one of the most popular platforms for assessing DNA methylation with over 10,000 samples available in the public domain. However, accessing all this data requires downloading each individual experiment and due to inconsistent annotation, accessing the right data can be a challenge. Here we introduce 'Marmal-aid', the first standardised database for DNA methylation (freely available at http://marmal-aid.org). In Marmal-aid, the majority of publicly available Illumina HumanMethylation450 data is incorporated into a single repository allowing for re-processing of data including normalisation and imputation of missing values. The database is accessible in two ways: (1) Using an R package to allow for incorporation into existing analysis pipelines which can then be easily queried to gain insight into the functionality of certain CpG sites. This is aimed at a bioinformatician with experience in R. (2) Using a graphical interface allowing general biologists to query a pre-defined set of tissues (currently 15) providing a reference database of the methylation state in these tissues for the 450,000 CpG sites profiled by the Illumina HumanMethylation450. Marmal-aid is the largest publicly available Illumina HumanMethylation450 methylation database combining Illumina HumanMethylation450 data from a number of sources into a single location with a single common annotation format. This allows for automated extraction using the R package and inclusion into existing analysis pipelines."
According to the news editors, the research concluded: "Marmal-aid also provides a easy to use GUI to visualise methylation data in user defined genomic regions for various reference tissues."
For more information on this research see: Marmal-aid--a database for Infinium HumanMethylation450. Bmc Bioinformatics, 2013;14():359. (BioMed Central - www.biomedcentral.com/; Bmc Bioinformatics - www.biomedcentral.com/bmcbioinformatics/)
Our news journalists report that additional information may be obtained by contacting R. Lowe, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Keywords for this news article include: London, Europe, DNA Research, United Kingdom, Biotechnology Companies.
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