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Research Data from University of Western Ontario Update Understanding of Nanoparticles

February 3, 2014

By a News Reporter-Staff News Editor at Diabetes Week -- Researchers detail new data in Nanoparticles. According to news reporting out of London, Canada, by NewsRx editors, research stated, "Fluorescence technique is one of the major solutions for achieving the continuous and noninvasive glucose sensor for diabetes. In this article, a highly sensitive nanostructured sensor is developed to detect extremely small amounts of aqueous glucose by applying fluorescence energy transfer (FRET)."

Our news journalists obtained a quote from the research from the University of Western Ontario, "A one-pot method is applied to produce the dextran-fluorescein isothiocyanate (FITC)-conjugating mesoporous silica nanoparticles (MSNs), which afterward interact with the tetramethylrhodamine isothiocyanate (TRITC)-labeled concanavalin A (Con A) to form the FRET nanoparticles (FITC-dextran-Con A-TRITC@MSNs). The nanostructured glucose sensor is then formed via the self-assembly of the FRET nanoparticles on a transparent, flexible, and biocompatible substrate, e.g., poly(dimethylsiloxane). Our results indicate the diameter of the MSNs is 60 5 nm. The difference in the images before and after adding 20 ?l of glucose (0.10 mmol/liter) on the FRET sensor can be detected in less than 2 min by the laser confocal laser scanning microscope. The correlation between the ratio of fluorescence intensity, I(donor)/I(acceptor), of the FRET sensor and the concentration of aqueous glucose in the range of 0.04-4 mmol/liter has been investigated; a linear relationship is found. Furthermore, the durability of the nanostructured FRET sensor is evaluated for 5 days. In addition, the recorded images can be converted to digital images by obtaining the pixels from the resulting matrix using Matlab image processing functions. We have also studied the in vitro cytotoxicity of the device."

According to the news editors, the research concluded: "The nanostructured FRET sensor may provide an alternative method to help patients manage the disease continuously."

For more information on this research see: Harnessing a nanostructured fluorescence energy transfer sensor for quick detection of extremely small amounts of glucose. Journal of Diabetes Science and Technology, 2013;7(1):45-52 (see also Nanoparticles).

Our news journalists report that additional information may be obtained by contacting J. Zhang, Dept. of Chemical and Biochemical Engineering, University of Western Ontario, London, Ontario, Canada. Additional authors for this research include X. Wang, L. Chen, J. Li and K. Luzak.

Keywords for this news article include: London, Canada, Ontario, Nanotechnology, Emerging Technologies, North and Central America.

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Source: Diabetes Week

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