News Column

Reports Outline Diabetes Findings from University of California

February 7, 2014

By a News Reporter-Staff News Editor at Angiogenesis Weekly -- Researchers detail new data in Diabetes. According to news reporting originating in Davis, California, by NewsRx journalists, research stated, "Phase-variance optical coherence tomography (PV-OCT) provides volumetric imaging of the retinal vasculature without the need for intravenous injection of a fluorophore. We compare images from PV-OCT and fluorescein angiography (FA) for normal individuals and patients with age-related macular degeneration (AMD) and diabetic retinopathy."

The news reporters obtained a quote from the research from the University of California, "This is an evaluation of a diagnostic technology. Four patients underwent comparative retinovascular imaging using FA and PV-OCT. Imaging was performed on 1 normal individual, 1 patient with dry AMD, 1 patient with exudative AMD, and 1 patient with nonproliferative diabetic retinopathy. Fluorescein angiography imaging was performed using a Topcon Corp (Tokyo, Japan) (TRC-50IX) camera with a resolution of 1280 (H) x 1024 (V) pixels. The PV-OCT images were generated by software data processing of the entire cross-sectional image from consecutively acquired B-scans. Bulk axial motion was calculated and corrected for each transverse location, reducing the phase noise introduced from eye motion. Phase variance was calculated through the variance of the motion-corrected phase changes acquired within multiple B-scans at the same position. Repeating these calculations over the entire volumetric scan produced a 3-dimensional PV-OCT representation of the vasculature. Feasibility of rendering retinal and choroidal microvasculature using PV-OCT was compared qualitatively with FA, the current gold standard for retinovascular imaging. Phase-variance OCT noninvasively rendered a 2-dimensional depth color-coded vasculature map of the retinal and choroidal vasculature. The choriocapillaris was imaged with better resolution of microvascular detail using PV-OCT. Areas of geographic atrophy and choroidal neovascularization imaged by FA were depicted by PV-OCT. Regions of capillary nonperfusion from diabetic retinopathy were shown by both imaging techniques; there was not complete correspondence between microaneurysms shown on FA and PV-OCT images."

According to the news reporters, the research concluded: "Phase-variance OCT yields high-resolution imaging of the retinal and choroidal microvasculature that compares favorably with FA."

For more information on this research see: Phase-Variance Optical Coherence Tomography A Technique for Noninvasive Angiography. Ophthalmology, 2014;121(1):180-187. Ophthalmology can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Ophthalmology -

Our news correspondents report that additional information may be obtained by contacting D.M. Schwartz, University of California, Dept. of Ophthalmol & Vis Sci, Davis, CA 95616, United States. Additional authors for this research include J. Fingler, D.Y. Kim, R.J. Zawadzki, L.S. Morse, S.S. Park, S.E.Fraser and J.S. Werner (see also Diabetes).

Keywords for this news article include: Davis, Diabetes, California, Cardiology, Angiography, Eye Diseases, United States, Endocrinology, Ophthalmology, Retinal Diseases, Vascular Diseases, Imaging Technology, Diabetic Retinopathy, Diabetic Angiopathies, North and Central America, Optical Coherence Tomography, Age-Related Macular Degeneration

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Source: Angiogenesis Weekly

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