News Column

Report Summarizes Gene Therapy Study Findings from University of Applied Sciences

February 6, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Fresh data on Biotechnology are presented in a new report. According to news reporting originating from Giessen, Germany, by NewsRx correspondents, research stated, "Industrial manufacturing of cell culture-derived viruses or virus-like particles for gene therapy or vaccine production are complex multistep processes. In addition to the bioreactor, such processes require a multitude of downstream unit operations for product separation, concentration, or purification."

Our news editors obtained a quote from the research from the University of Applied Sciences, "Similarly, before a biopharmaceutical product can enter the market, removal or inactivation of potential viral contamination has to be demonstrated. Given the complexity of biological solutions and the high standards on composition and purity of biopharmaceuticals, downstream processing is the bottleneck in many biotechnological production trains. Membrane-based filtration can be an economically attractive and efficient technology for virus separation. Viral clearance, for instance, of up to seven orders of magnitude has been reported for state of the art polymeric membranes under best conditions.This chapter summarizes the fundamentals of virus ultrafiltration, diafiltration, or purification with adsorptive membranes. In lieu of an impractical universally applicable protocol for virus filtration, application of these principles is demonstrated with two examples."

According to the news editors, the research concluded: "The chapter provides detailed methods for production, concentration, purification, and removal of a rod-shaped baculovirus (Autographa californica M nucleopolyhedrovirus, about 40 x 300 nm in size, a potential vector for gene therapy, and an industrially important protein expression system) or a spherical parvovirus (minute virus of mice, 22-26 nm in size, a model virus for virus clearance validation studies)."

For more information on this research see: Virus separation using membranes. Methods In Molecular Biology, 2014;1104():459-91 (see also Biotechnology).

The news editors report that additional information may be obtained by contacting T.A. Grein, Institute of Bioprocess Engineering and Pharmaceutical Technology, University of Applied Sciences Mittelhessen, Giessen, Germany. Additional authors for this research include R. Michalsky and P. Czermak.

Keywords for this news article include: Biotechnology, Europe, Giessen, Germany, Viruses, Virology, Gene Therapy, Bioengineering.

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Source: Gene Therapy Weekly

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