By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Erythroid Cells. According to news reporting originating in Boston, Massachusetts, by NewsRx journalists, research stated, "During the course of their lifespan, erythrocytes actively shed phospholipid-bound microvesicles (MVs). In stored blood, the number of these erythrocyte-derived MVs has been observed to increase over time, suggesting their potential value as a quality metric for blood products."
The news reporters obtained a quote from the research from Harvard University, "The lack of sensitive, standardized MV assays, however, poses a significant barrier to implementing MV analyses into clinical settings. Here, we report on a new nanotechnology platform capable of rapid and sensitive MV detection in packed red blood cell (pRBC) units. A filter-assisted microfluidic device was designed to enrich MVs directly from pRBC units, and label them with target-specific magnetic nanoparticles. Subsequent detection using a miniaturized nuclear magnetic resonance system enabled accurate MV quantification as well as the detection of key molecular markers (CD44, 047, CD55). When the developed platform was applied, MVs in stored blood units could also be monitored longitudinally. Our results showed that MV counts increase over time and, thus, could serve as an effective metric of blood aging. Furthermore, our studies found that MVs have the capacity to generate oxidative stress and consume nitric oxide."
According to the news reporters, the research concluded: "By advancing our understanding of MV biology, we expect that the developed platform will lead to improved blood product quality and transfusion safety."
For more information on this research see: Magnetic Nanosensor for Detection and Profiling of Erythrocyte-Derived Microvesicles. ACS Nano, 2013;7(12):11227-11233. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting J. Rho, Harvard University, Sch Med, Dept. of Syst Biol, Boston, MA 02115, United States. Additional authors for this research include J. Chung, H. Im, M. Liong, H.L. Shao, C.M. Castro, R. Weissleder and H. Lee (see also Erythroid Cells).
Keywords for this news article include: Boston, Immunology, Blood Cells, Erythrocytes, Massachusetts, United States, Erythroid Cells, North and Central America
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