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Patent Issued for Assessment of Pulmonary Vascular Resistance via Pulmonary Artery Pressure

February 3, 2014

By a News Reporter-Staff News Editor at Cardiovascular Week -- A patent by the inventors Stahmann, Jeffrey E. (Ramsey, MN); Siejko, Krzysztof Z. (Maple Grove, MN), filed on September 24, 2009, was published online on January 21, 2014, according to news reporting originating from Alexandria, Virginia, by NewsRx correspondents (see also Cardiac Pacemakers, Inc.).

Patent number 8632470 is assigned to Cardiac Pacemakers, Inc. (St. Paul, MN).

The following quote was obtained by the news editors from the background information supplied by the inventors: "Pulmonary vascular resistance (PVR) is an important hemodynamic variable that affects prognosis and therapy in a wide range of cardiovascular and pulmonary conditions. In the diagnosis and treatment of cardiogenic pulmonary edema, for example, pulmonary vascular resistance can be used as an indicator for the distension of small pulmonary vessels, which typically occurs in early stages of heart decompensation in response to elevated left atrial pressures. In addition to the diagnosis and treatment of pulmonary edema, pulmonary vascular resistance can also be utilized as an indicator for other conditions, including pulmonary hypertension, pulmonary embolisms, and atelectasis. Since changes in pulmonary vascular resistance often occur in the early stage of diseases such as pulmonary edema, the periodic measurement of this parameter over time may provide a useful indicator for the early detection of an acutely worsening heart failure.

"A variety of different techniques have been employed for measuring pulmonary vascular resistance. In one such method disclosed in U.S. Pat. No. 7,204,798, for example, an inflatable balloon catheter is used to induce a change in volume and/or pressure within a heart chamber during systole, and then inject a fluid into the heart chamber during diastole. A sensor is then used to measure the pressure and/or volume at a location within the heart (e.g., the left ventricle or aorta), which can then be used to compute various hemodynamic parameters, including pulmonary vascular resistance. While providing a means for calculating pulmonary vascular resistance, such methods typically require the insertion of a catheter within the body, and are therefore not useful in measuring long term trends that occur over longer periods of time."

In addition to the background information obtained for this patent, NewsRx journalists also obtained the inventors' summary information for this patent: "The present invention pertains to methods and systems for measuring pulmonary or systemic vascular resistance within a patient. An illustrative method of measuring pulmonary vascular resistance within a patient includes electrically inducing a retrograde pressure pulse within the patient's heart using a pulse generator, sensing at least one arterial pressure parameter in response to the retrograde pressure pulse using a pressure sensor located within a pulmonary artery, and computing a value of the change in pulmonary vascular resistance using the at least one sensed arterial pressure parameter. In some embodiments, data from multiple pulmonary vascular resistance assessments can be trended over a period of time to aid in detecting an underlying cardiovascular or pulmonary condition such as cardiogenic pulmonary edema.

"An illustrative system for measuring pulmonary vascular resistance within a patient includes a pulse generator including at least one lead adapted to induce a retrograde pressure pulse within the left atrium of the heart, a pressure sensor implanted within a pulmonary artery and adapted to sense an arterial pressure waveform in response to the retrograde pressure pulse, and a processor adapted to compute a value of pulmonary vascular resistance using the sensed arterial pressure waveform. The processor may comprise a component or module of the pulse generator, the pressure sensor, or an external monitoring device in communication with the pulse generator and/or pressure sensor.

"While multiple embodiments are disclosed, still other embodiments of the present invention will become apparent to those skilled in the art from the following detailed description, which shows and describes illustrative embodiments of the invention. Accordingly, the drawings and detailed description are to be regarded as illustrative in nature and not restrictive."

URL and more information on this patent, see: Stahmann, Jeffrey E.; Siejko, Krzysztof Z.. Assessment of Pulmonary Vascular Resistance via Pulmonary Artery Pressure. U.S. Patent Number 8632470, filed September 24, 2009, and published online on January 21, 2014. Patent URL:

Keywords for this news article include: Angiology, Treatment, Lung Diseases, Pulmonary Edema, Cardiac Pacemakers Inc., Respiratory Tract Diseases.

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Source: Cardiovascular Week

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