By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Current study results on Nanoparticles have been published. According to news reporting originating from Beijing, People's Republic of China, by NewsRx correspondents, research stated, "Wrapping dendrimer-like soft nanoparticles by cell membrane is an essential event in their endocytosis in drug and gene delivery, but this process remains poorly elucidated. Using computer simulations and theoretical analysis, we report the detailed dynamics of the process in which a lipid bilayer membrane fully wraps a dendrimer-like soft nanoparticle."
Our news editors obtained a quote from the research from Tsinghua University, "By constructing a phase diagram, we firstly demonstrate that there exist three states in the interaction between a dendrimer and a lipid bilayer membrane, i.e., penetration, penetration and partial wrapping, and full wrapping states. The wrapping process of dendrimer-like nanoparticles is found to take a unique approach where the penetration of the dendrimer into the membrane plays a significant role. The analysis of various energies within the system provides a theoretical justification to the state transition observed from simulations. The findings also support recent experimental results and provide a theoretical explanation for them."
According to the news editors, the research concluded: "We expect that these findings are of immediate interest to the study of the cellular uptake of dendrimer-like soft nanoparticles and can prompt the further application of this class of nanoparticles in nanomedicine."
For more information on this research see: Unique Dynamical Approach of Fully Wrapping Dendrimer-like Soft Nanoparticles by Lipid Bilayer Membrane. ACS Nano, 2013;7(12):10646-10653. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
The news editors report that additional information may be obtained by contacting R.H. Guo, Tsinghua Univ, Dept. of Chem Engn, Key Lab Adv Mat MOE, Beijing 100084, People's Republic of China. Additional authors for this research include J. Mao and L.T. Yan (see also Nanoparticles).
Keywords for this news article include: Asia, Biotechnology, Beijing, Gene Therapy, Bioengineering, Nanotechnology, Emerging Technologies, People's Republic of China
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