News Column

New Findings from University of Illinois in Diencephalon Provides New Insights

February 3, 2014

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Current study results on Central Nervous System have been published. According to news reporting from Urbana, Illinois, by NewsRx journalists, research stated, "Key questions about the thalamus are still unanswered in part because of the inability to stimulate its inputs while monitoring cortical output. To address this, we employed flavoprotein autofluorescence optical imaging to expedite the process of developing a brain slice in mouse with connectivity among the auditory midbrain, thalamus, thalamic reticular nucleus, and cortex."

The news correspondents obtained a quote from the research from the University of Illinois, "Optical, electrophysiological, anatomic, and pharmacological tools revealed ascending connectivity from midbrain to thalamus and thalamus to cortex as well as descending connectivity from cortex to thalamus and midbrain and from thalamus to midbrain. The slices were relatively thick (600-700 mu m), but, based on typical measures of cell health (resting membrane potential, spike height, and input resistance) and use of 2,3,5-triphenyltetrazolium chloride staining, the slices were as viable as thinner slices. As expected, after electrical stimulation of the midbrain, the latency of synaptic responses gradually increased from thalamus to cortex, and spiking responses were seen in thalamic neurons. Therefore, for the first time, it will be possible to manipulate and record simultaneously the activity of most of the key brain structures that are synaptically connected to the thalamus."

According to the news reporters, the research concluded: "The details for the construction of such slices are described herein."

For more information on this research see: An auditory colliculothalamocortical brain slice preparation in mouse. Journal of Neurophysiology, 2014;111(1):197-207. Journal of Neurophysiology can be contacted at: Amer Physiological Soc, 9650 Rockville Pike, Bethesda, MD 20814, USA (see also Central Nervous System).

Our news journalists report that additional information may be obtained by contacting D.A. Llano, University of Illinois, Coll Med, Urbana, IL, United States. Additional authors for this research include B.J. Slater, A.M.H. Lesicko and K.A. Stebbings.

Keywords for this news article include: Brain, Urbana, Illinois, Thalamus, Diencephalon, United States, Central Nervous System, North and Central America

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Source: Pain & Central Nervous System Week

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