By a News Reporter-Staff News Editor at Computer Weekly News -- Investigators publish new report on Biochemistry. According to news reporting out of Madison, Wisconsin, by VerticalNews editors, research stated, "System-level analyses of microbial metabolism are facilitated by genome-scale reconstructions of microbial biochemical networks. A reconstruction provides a structured representation of the biochemical transformations occurring within an organism, as well as the genes necessary to carry out these transformations, as determined by the annotated genome sequence and experimental data."
Our news journalists obtained a quote from the research from the University of Wisconsin, "Network reconstructions also serve as platforms for constraint-based computational techniques, which facilitate biological studies in a variety of applications, including evaluation of network properties, metabolic engineering and drug discovery. Bottom-up metabolic network reconstructions have been developed for dozens of organisms, but until recently, the pace of reconstruction has failed to keep up with advances in genome sequencing. To address this problem, a number of software platforms have been developed to automate parts of the reconstruction process, thereby alleviating much of the manual effort previously required. Here, we review four such platforms in the context of established guidelines for network reconstruction. While many steps of the reconstruction process have been successfully automated, some manual evaluation of the results is still required to ensure a high-quality reconstruction."
According to the news editors, the research concluded: "Widespread adoption of these platforms by the scientific community is underway and will be further enabled by exchangeable formats across platforms."
For more information on this research see: Software platforms to facilitate reconstructing genome-scale metabolic networks. Environmental Microbiology, 2014;16(1):49-59. Environmental Microbiology can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Environmental Microbiology - onlinelibrary.wiley.com/journal/10.1111/(ISSN)1462-2920)
Our news journalists report that additional information may be obtained by contacting J.J. Hamilton, University of Wisconsin, Dept. of Chem & Biol Engn, Madison, WI 53706, United States.
Keywords for this news article include: Madison, Software, Wisconsin, Biochemical, Biochemistry, United States, North and Central America
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