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Investigators at Osaka University Report Findings in Age-Related Macular Degeneration

February 3, 2014

By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on Age-Related Macular Degeneration. According to news reporting from Osaka, Japan, by NewsRx journalists, research stated, "We compared the visibility of retinal and choroidal pathologies using high-penetration optical coherence tomography (HP-OCT) with a long-wavelength light source (1,050 nm) and conventional spectral-domain OCT (SD-OCT) in age-related macular degeneration (AMD). One hundred and forty-six eyes were included: 63 eyes with AMD, 79 eyes with polypoidal choroidal vasculopathy (PCV), and four eyes with retinal angiomatous proliferation."

The news correspondents obtained a quote from the research from Osaka University, "The SD-OCT and HP-OCT images were compared using the grading criteria to grade the visibility of the retinal changes, the line corresponding to the retinal pigment epithelium (RPE), and the chorioscleral interface (CSI). In 132 eyes with a pigment epithelial detachment (PED), we graded the structures inside the PED, Bruch's line, and the CSI. We compared the visibility of those changes in eyes with subretinal hyperreflective changes due to a subretinal hemorrhage (SRH) (n = 17) or a hemorrhage inside the PED (HPED) (n = 12). HP-OCT provided superior visibility of the following structures compared to SD-OCT (P < 0.01): the CSI, structures inside the PED, Bruch's line inside the PED, the CSI inside the PED, SRH, type 1 CNV, polyps, and HPED. There were no significant differences between the two OCT devices in the scores for the RPE line, retinal morphology, or type 2 CNV and/or fibrin."

According to the news reporters, the research concluded: "HP-OCT visualizes morphologies beneath the RPE better than SD-OCT, and is equivalent to SD-OCT for visualizing morphologies above the RPE."

For more information on this research see: Comparison of spectral-domain and high-penetration OCT for observing morphologic changes in age-related macular degeneration and polypoidal choroidal vasculopathy. Graefes Archive for Clinical and Experimental Ophthalmology, 2014;252(1):3-9. Graefes Archive for Clinical and Experimental Ophthalmology can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA (see also Age-Related Macular Degeneration).

Our news journalists report that additional information may be obtained by contacting K. Sayanagi, Osaka University, Sch Med, Dept. of Ophthalmol E7, Suita, Osaka 5650871, Japan. Additional authors for this research include F. Gomi, Y. Ikuno, M. Akiba and K. Nishida.

Keywords for this news article include: Asia, Osaka, Japan, Retinal Diseases, Retinal Degeneration, Age-Related Macular Degeneration

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Source: Pain & Central Nervous System Week

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