"This important notice of allowance represents a major step towards exclusivity in
In preclinical tests conducted by iBio, an HPV16 E7 coding sequence was engineered as a fusion protein with a modified (beta)-1,3-1,4 glucanase (iBioModulator) of Clostridium thermocellum. It was manufactured in whole Nicotiana benthamiana plants by transient expression using the company's iBioLaunch™ vector system. Immunization with E7-iBioModulator fusion protein resulted in a prophylactic effect, as well as a therapeutic response clearing tumors in experimentally-implanted animals.
The iBioModulator platform has been shown to significantly modify the immune response to a vaccine in two important ways. First, it increases the strength of the initial immune response to a vaccine antigen (as measured by antibody titer). Then it extends the duration of the immune response, thus lowering vaccine antigen requirements or enabling fewer doses to establish prolonged immunity. Generating a stronger immune response and longer-term protection without booster inoculations adds significant value to a vaccine by reducing the overall costs and logistical difficulties of its use while effectively reaching a higher proportion of the target population.
The iBioModulator platform is supported by iBio's proprietary iBioLaunch plant-based protein expression system. iBio offers iBioModulator licenses to product developers for use with iBioLaunch or other protein expression systems.
The new patent allowance complements iBio's Australian version of the patent (serial no. 2007215082) that was issued in October of 2012. It also broadens the protection of iBio's greater patent family, particularly U.S. Patents 8,173,408 and 8,591,909, Canadian Patent 2,526,720, and European Patent 1,664,322, all of which cover compositions and uses of the company's iBioModulator vaccine platform. iBio's IP portfolio now includes a total of 12 U.S. and 18 international patents, with 13 U.S. and 36 international patent applications.
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