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Findings on Osteosarcomas Reported by Investigators at King Abdul-Aziz University

February 3, 2014

By a News Reporter-Staff News Editor at Clinical Oncology Week -- Current study results on Oncology have been published. According to news reporting originating in Jeddah, Saudi Arabia, by NewsRx journalists, research stated, "Curcumin is a natural phenolic compound extracted from the plant Curcuma longa L. In previous studies, curcumin has been shown to have anticancer, antioxidant, and anti-inflammatory effects. In this study, the cytotoxicity of different concentrations (5, 10, 25, 50, 75, and 100 mu M) of curcumin dissolved in dimethyl sulfoxide was compared between MG-63 osteosarcoma and healthy human osteoblast cells."

The news reporters obtained a quote from the research from King Abdul-Aziz University, "Consequently, the viability of osteosarcoma cells was less than 50% at a concentration of 10 mu M compared to the control sample without curcumin, but healthy osteoblast cells had at least 80% viability throughout all the concentrations tested. The results demonstrated that MG-63 osteosarcoma cells were much more sensitive in terms of cytotoxicity to curcumin, while the healthy human osteoblasts exhibited a higher healthy viability after 24 hours of curcumin treatment."

According to the news reporters, the research concluded: "Therefore, this study showed that at the right concentrations (5 mu M to 25 mu M), curcumin, along with a proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells."

For more information on this research see: Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts. International Journal of Nanomedicine, 2014;9():461-465. International Journal of Nanomedicine can be contacted at: Dove Medical Press Ltd, PO Box 300-008, Albany, Auckland 0752, New Zealand (see also Oncology).

Our news correspondents report that additional information may be obtained by contacting R. Chang, King Abdulaziz Univ, Center Excellence Adv Mat Res, Jeddah 21413, Saudi Arabia. Additional authors for this research include L.L. Sun and T.J. Webster.

Keywords for this news article include: Asia, Jeddah, Alkanes, Curcumin, Oncology, Catechols, Orthopedics, Osteoblasts, Saudi Arabia, Hydrocarbons, Osteosarcoma, Diarylheptanoids, Organic Chemicals, Connective Tissue Cells

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Clinical Oncology Week

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