By a News Reporter-Staff News Editor at Health & Medicine Week -- Researchers detail new data in Nanotechnology. According to news reporting originating from Clayton, Australia, by NewsRx correspondents, research stated, "The usefulness of zinc oxide (ZnO) nanoparticles has led to their wide distribution in consumer products, despite only a limited understanding of how this nanomaterial behaves within biological systems. From a nanotoxicological viewpoint the interaction(s) of ZnO nanoparticles with cells of the immune system is of specific interest, as these nanostructures are readily phagocytosed."
Our news editors obtained a quote from the research from Monash University, "In this study, rapid scanning X-ray fluorescence microscopy was used to assay the number ZnO nanoparticles associated with similar to 1000 individual THP-1 monocyte-derived human macrophages. These data showed that nanoparticle-treated cells endured a 400% elevation in total Zn levels, 13-fold greater than the increase observed when incubated in the presence of an equitoxic concentration of ZnCl2. Even after excluding the contribution of internalized nanoparticles, Zn levels in nanoparticle treated cells were raised similar to 200% above basal levels. As dissolution of ZnO nanoparticles is critical to their cytotoxic response, we utilized a strategy combining ion beam milling, X-ray fluorescence and scanning electron microscopy to directly probe the distribution and composition of ZnO nanoparticles throughout the cellular interior. This study demonstrated that correlative photon and ion beam imaging techniques can provide both high-resolution and statistically powerful information on the biology of metal oxide nanoparticles at the single-cell level."
According to the news editors, the research concluded: "Our approach promises ready application to broader studies of phenomena at the interface of nanotechnology and biology."
For more information on this research see: Quantification of ZnO Nanoparticle Uptake, Distribution, and Dissolution within Individual Human Macrophages. ACS Nano, 2013;7(12):10621-10635. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
The news editors report that additional information may be obtained by contacting S.A. James, Monash University, Dept. of Mech & Aerosp Engn, Clayton, Vic 3800, Australia. Additional authors for this research include B.N. Feltis, M.D. de Jonge, M. Sridhar, J.A. Kimpton, M. Altissimo, S. Mayo, C.X. Zheng, A. Hastings, D.L. Howard, D.J. Paterson, P.F.A. Wright, G.F. Moorhead, T.W. Turney and J. Fu (see also Nanotechnology).
Keywords for this news article include: Clayton, Immunology, Zinc Oxide, Macrophages, Nanoparticle, Myeloid Cells, Nanotechnology, Emerging Technologies, Connective Tissue Cells, Australia and New Zealand, Mononuclear Phagocyte System
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