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Studies from University of Jordan in the Area of Nanoparticles Described

January 31, 2014

By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Nanoparticles. According to news reporting from Amman, Jordan, by NewsRx journalists, research stated, "Thymoquinone (TQ) was complexed with beta-cyclodextrin (CD) to form nanosized aggregates. Various TQ:CD ratios were tested and it was found that the ratio of (1:0.25) TQ:CD formed distinguishable nanoparticles with minimum toxicity towards normal cells."

The news correspondents obtained a quote from the research from the University of Jordan, "These nanoparticles had an average size of 445 100 nm with a charge 21.8 mV using Zeta-sizer. Particle size measurement using scanning electron microscopy (SEM) showed an average size of 400 nm and it also revealed the presence of smaller structures, with an average size of 50 nm. The in vitro antiproliferative activity on MCF7 cells was determined using MTT assay and an IC50 of 4.70 0.60 microM for TQ-CD nanoparticles in comparison to 24.09 2.35 microM of free TQ solution after 72 h of incubation. Simultaneously, TQ-CD nanoparticles showed lesser toxicity than TQ solution using human periodontal fibroblasts as a model for normal cells."

According to the news reporters, the research concluded: "It could be concluded from the results that TQ loaded cyclodextrin nanoparticles might serve as a potential nanocarrier to improve TQ solubility as well as its antiproliferative activity with little toxicity to normal tissues."

For more information on this research see: Preparation, characterization and antiproliferative activity of thymoquinone-beta-cyclodextrin self assembling nanoparticles. Pharmazie, 2013;68(12):939-44. Pharmazie can be contacted at: Govi-Verlag GmbH, Pharmazeutischer Verlag Ginnheimer Strasse 26, D-65760 Eschborn, Germany. (Wiley-Blackwell -; Pharmazie -

Our news journalists report that additional information may be obtained by contacting R. Abu-Dahab, Dept. of Biopharmaceutics and Clinical Pharmacy, School of Medicine, The University of Jordan, Amman, Jordan. Additional authors for this research include F. Odeh, S.I. Ismail, H. Azzam and A. Al Bawab (see also Nanoparticles).

Publisher contact information for the journal Pharmazie is: Govi-Verlag GmbH, Pharmazeutischer Verlag Ginnheimer Strasse 26, D-65760 Eschborn, Germany.

Keywords for this news article include: Asia, Amman, Jordan, Nanotechnology, Emerging Technologies.

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Source: Drug Week

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