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Studies from Deaconess Medical Center Add New Findings in the Area of Biotechnology

January 29, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Fresh data on Technology are presented in a new report. According to news reporting originating from Boston, Massachusetts, by NewsRx correspondents, research stated, "The signal-to-background ratio (SBR) is the key determinant of sensitivity, detectability and linearity in optical imaging. As signal strength is often constrained by fundamental limits, background reduction becomes an important approach for improving the SBR."

Our news editors obtained a quote from the research from Deaconess Medical Center, "We recently reported that a zwitterionic near-infrared (NIR) fluorophore, ZW800-1, exhibits low background. Here we show that this fluorophore provides a much-improved SBR when targeted to cancer cells or proteins by conjugation with a cyclic RGD peptide, fibrinogen or antibodies. ZW800-1 outperforms the commercially available NIR fluorophores IRDye800-CW and Cy5.5 in vitro for immunocytometry, histopathology and immunoblotting and in vivo for image-guided surgery. In tumor model systems, a tumor-to-background ratio of 17.2 is achieved at 4 h after injection of ZW800-1 conjugated to cRGD compared to ratios of 5.1 with IRDye800-CW and 2.7 with Cy5.5."

According to the news editors, the research concluded: "Our results suggest that introducing zwitterionic properties into targeted fluorophores may be a general strategy for improving the SBR in diagnostic and therapeutic applications."

For more information on this research see: Targeted zwitterionic near-infrared fluorophores for improved optical imaging. Nature Biotechnology, 2013;31(2):148-53. (Nature Publishing Group -; Nature Biotechnology -

The news editors report that additional information may be obtained by contacting H.S. Choi, Dept. of Medicine, Division of Hematology, Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States. Additional authors for this research include S.L. Gibbs, J.H. Lee, S.H. Kim, Y. Ashitate, F. Liu, H. Hyun, G. Park, Y. Xie, S. Bae, M. Henary and J.V Frangioni (see also Technology).

Keywords for this news article include: Boston, Technology, Massachusetts, United States, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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