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Studies from Amrita University Have Provided New Information about Diabetes

January 27, 2014

By a News Reporter-Staff News Editor at Diabetes Week -- New research on Diabetes is the subject of a report. According to news reporting originating from Kochi, India, by NewsRx correspondents, research stated, "The aim of this work was to develop an antimicrobial sponge composed of chitosan, hyaluronic acid (HA) and nano silver (nAg) as a wound dressing for diabetic foot ulcers (DFU) infected with drug resistant bacteria. nAg (5-20 nm) was prepared and characterized. The nanocomposite sponges were prepared by homogenous mixing of chitosan, HA and nAg followed by freeze drying to obtain a flexible and porous structure."

Our news editors obtained a quote from the research from Amrita University, "The prepared sponges were characterized using SEM and FT-IR. The porosity, swelling, biodegradation and haemostatic potential of the sponges were also studied. Antibacterial activity of the prepared sponges was analysed using Escherichia coli, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa and Klebsiella pneumonia. Chitosan-HA/nAg composite sponges showed potent antimicrobial property against the tested organisms. Sponges containing higher nAg (0.005%, 0.01% and 0.02%) concentrations showed antibacterial activity against MRSA. Cytotoxicity and cell attachment studies were done using human dermal fibroblast cells. The nanocomposite sponges showed a nAg concentration dependent toxicity towards fibroblast cells."

According to the news editors, the research concluded: "Our results suggest that this nanocomposite sponges could be used as a potential material for wound dressing for DFU infected with antibiotic resistant bacteria if the optimal concentration of nAg exhibiting antibacterial action with least toxicity towards mammalian cells is identified."

For more information on this research see: Chitosan-hyaluronic acid/nano silver composite sponges for drug resistant bacteria infected diabetic wounds. International Journal of Biological Macromolecules, 2013;62():310-20. (Elsevier -; International Journal of Biological Macromolecules -

The news editors report that additional information may be obtained by contacting B.S. Anisha, Amrita Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham University, Kochi 682041, India. Additional authors for this research include R. Biswas, K.P. Chennazhi and R. Jayakumar (see also Diabetes).

Keywords for this news article include: Asia, Antibacterial, Antibiotics, Antimicrobials, Kochi, India, Therapy, Diabetes, Endocrinology.

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Source: Diabetes Week

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