By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on Neurodegenerative Diseases have been published. According to news reporting out of Delhi, India, by NewsRx editors, research stated, "For some instances of Parkinson disease (PD), current evidence in the literature is consistent with reactive oxygen species being involved in the etiology of the disease. The management of PD is still challenging owing to its ambiguous etiology and lack of permanent cure."
Our news journalists obtained a quote from the research from the Council of Scientific and Industrial Research (CSIR), "Because nicotine offers neuroprotection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism, the neuroprotective efficacy of nicotine-encapsulated poly(lactic-co-glycolic) acid (PLGA) nanoparticles and the underlying mechanism of improved efficacy, if any, over bulk nicotine were assessed in this study. The selected indicators of oxidative stress, dopaminergic neurodegeneration and apoptosis, were measured in both in vitro and rodent models of parkinsonism in the presence or absence of 'nanotized' or bulk nicotine. The levels of dopamine and its metabolites were measured in the striatum, nicotine and its metabolite in the nigrostriatal tissues while the immunoreactivities of tyrosine hydroxylase (TH), metallothionein-III (MT-III), inducible nitric oxide synthase (iNOS) and microglial activation were checked in the substantia nigra of controls and treated mice. GSTA4-4, heme oxygenase (HO)-1, tumor suppressor protein 53 (p53), caspase-3, lipid peroxidation (LPO), and nitrite levels were measured in the nigrostriatal tissues. Nicotine-encapsulated PLGA nanoparticles improved the endurance of TH-immunoreactive neurons and the number of fiber outgrowths and increased the mRNA expression of TH, neuronal cell adhesion molecule, and growth-associated protein-43 over bulk against 1-methyl-4-phenyl pyridinium ion-induced degeneration in the in vitro model. MPTP reduced TH immunoreactivity and levels of dopamine and its metabolites and increased microglial activation, expression of GSTA4-4, iNOS, MT-III, HO-1, p53, and caspase-3, and levels of nitrite and LPO. Whereas both bulk nicotine and nicotine-encapsulated PLGA nanoparticles modulated the changes toward controls, the modulation was more pronounced in nicotine-encapsulated PLGA nanoparticle-treated parkinsonian mice. The levels of nicotine and cotinine were elevated in nicotine-encapsulated PLGA nanoparticle-treated PD mouse brain compared with bulk."
According to the news editors, the research concluded: "The results obtained from this study demonstrate that nanotization of nicotine improves neuroprotective efficacy by enhancing its bioavailability and subsequent modulation in the indicators of oxidative stress and apoptosis."
For more information on this research see: Nicotine-encapsulated poly(lactic-co-glycolic) acid nanoparticles improve neuroprotective efficacy against MPTP-induced parkinsonism. Free Radical Biology and Medicine, 2013;65():704-718. Free Radical Biology and Medicine can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier - www.elsevier.com; Free Radical Biology and Medicine - www.elsevier.com/wps/product/cws_home/525469)
Our news journalists report that additional information may be obtained by contacting M.N. Tiwari, CSIR, Inst Genom & Integrat Biol, Delhi 110007, India. Additional authors for this research include S. Agarwal, P. Bhatnagar, N.K. Singhal, S.K. Tiwari, P. Kumar, L.K.S. Chauhan, D.K. Patel, R.K. Chaturvedi, M.P. Singh and K.C. Gupta (see also Neurodegenerative Diseases).
Keywords for this news article include: Asia, Delhi, India, Genetics, p53 Gene, Nanoparticle, Parkinsonism, Nanotechnology, Emerging Technologies, Parkinsonian Disorders, Neurodegenerative Diseases
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