News Column

Researchers from Chonnam National University Discuss Findings in Biotechnology and Bioengineering

January 27, 2014



By a News Reporter-Staff News Editor at Clinical Trials Week -- Investigators discuss new findings in Biotechnology. According to news reporting originating in Gwangju, South Korea, by NewsRx journalists, research stated, "A bacteria-based microrobot (bacteriobot) was proposed and investigated as a new type of active drug delivery system because of its useful advantages, such as active tumor targeting, bacteria-mediated tumor diagnosis, and therapy. In this study, we fabricated a bacteriobot with enhanced motility by selective attachment of flagellar bacteria (Salmonella typhimurium)."

The news reporters obtained a quote from the research from Chonnam National University, "Through selective bovine serum albumin (BSA) pattering on hydrophobic polystyrene (PS) microbeads, many S. typhimurium could be selectively attached only on the unpatterned surface of PS microbead. For the evaluation of the chemotactic motility of the bacteriobot, we developed a microfluidic chamber which can generate a stable concentration gradient of bacterial chemotactic chemicals. Prior to the evaluation of the bacteriobot, we first evaluated the directional chemotactic motility of S. typhimurium using the proposed microfluidic chamber, which contained a bacterial chemo-attractant (L-aspartic acid) and a chemo-repellent (NiSO4 ), respectively. Compared to density of the control group in the microfluidic chamber without any chemical gradient, S. typhimurium increased by about 16% in the L-aspartic acid gradient region and decreased by about 22% in the NiSO4 gradient region. Second, we evaluated the bacteriobot's directional motility by using this microfluidic chamber. The chemotactic directional motility of the bacteriobot increased by 14% and decreased by 13% in the concentration gradients of L-aspartic acid and NiSO4 , respectively. These results confirm that the bacteriobot with selectively patterned S. typhimurium shows chemotaxis motility very similar to that of S. typhimurium."

According to the news reporters, the research concluded: "Moreover, the directional motilities of the bacteria and bacteriobot could be demonstrated quantitatively through the proposed microfluidic chamber."

For more information on this research see: Motility analysis of bacteria-based microrobot (bacteriobot) using chemical gradient microchamber. Biotechnology & Bioengineering, 2014;111(1):134-43. (Wiley-Blackwell - www.wiley.com/; Biotechnology & Bioengineering - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-0290)

Our news correspondents report that additional information may be obtained by contacting D. Park, School of Mechanical Systems Engineering, Chonnam National University, Gwangju, 500-757, South Korea. Additional authors for this research include S.J. Park, S. Cho, Y. Lee, Y.K. Lee, J.J. Min, B.J. Park, S.Y. Ko, J.O. Park and S. Park (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Gwangju, South Korea, Clinical Trials and Studies.

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Source: Clinical Trials Week


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