News Column

Researchers from Assiut University Report Findings in Gene Therapy

January 30, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Researchers detail new data in Biotechnology. According to news reporting out of Torun, Poland, by NewsRx editors, research stated, "Topical administration is attractive and non-invasive gene delivery approach. It is simple and allows repeated administration."

Our news journalists obtained a quote from the research from Assiut University, "In addition, the skin is active immune surveillance site. Topical gene therapy, although promising for treatment of cancer, dermatological disorders, vaccination and autoimmune disease, has not progressed yet to clinical trials. The inability of nucleic acids to survive the extra- and intracellular environment and to permeate through the outermost layer of the skin, the stratum corneum, compromise the therapeutic outcomes of nucleic acids-based therapies. Nanostructured vehicles (e.g. transfersomes, niosomes, nanoemulsions, gemini-lipid nanoparticles and biphasic vesicles) have the ability to partially disrupt and perturb lipids that are found in the skin layers and deliver their nucleic acid cargos to their targeted subcellular compartments. However, the efficiency of these carriers is still inferior to other invasive methods (e.g. epidermal and intradermal injections). The goal of this review is to examine the critical parameters required to enhance the efficiency of the currently available nanostructured vehicles, for example, by combining them with minimally invasive techniques, such as, electroporation, iontophoresis, microneedles, ultrasound, gene gun and femtosecond laser."

According to the news editors, the research concluded: "The recent advances in engineering these nanovectors will be discussed with a focus on their future prospects."

For more information on this research see: Needle-free Gene Delivery Through the Skin: An Overview of Recent Strategies. Current Pharmaceutical Design, 2013;19(41):7301-7315. Current Pharmaceutical Design can be contacted at: Bentham Science Publ Ltd, Executive Ste Y-2, PO Box 7917, Saif Zone, 1200 Br Sharjah, U Arab Emirates. (Bentham Science Publishers -; Current Pharmaceutical Design -

Our news journalists report that additional information may be obtained by contacting M. Elsabahy, Assiut Univ, Fac Pharm, Torun, Poland (see also Biotechnology).

Keywords for this news article include: Biotechnology, Torun, Poland, Europe, Gene Therapy, Bioengineering, Clinical Trials and Studies

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Source: Gene Therapy Weekly

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