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Research from Justus-Liebig-University Yields New Findings on Stem Cells

January 31, 2014

By a News Reporter-Staff News Editor at Drug Week -- New research on Stem Cell Research is the subject of a report. According to news originating from Giessen, Germany, by NewsRx correspondents, research stated, "The prevention of implant-related infections is an important issue in medical research. The aim is to exploit the strong antimicrobial effect of silver nanoparticles (AgNP) to develop new antibacterial coatings for implants."

Our news journalists obtained a quote from the research from Justus-Liebig-University, "However, there is still a serious lack of information on the influence of AgNP on bone metabolism. In the present study we have evaluated the influence of AgNP on cell stress, viability, proliferation and differentiation of primary human mesenchymal stem cells (MSC) and osteoblasts (OB). Finally, cellular uptake of the AgNP was examined. After 21 days impairment of cell viability of MSC and OB occurred at a concentration of 10 ?g/g of AgNP. Cytotoxicity and inhibition of proliferation was highly time and dose dependent. No influence on cell differentiation, but an increase in cell stress, was observed. Uptake of AgNP into MSC and OB could be confirmed. In summary, these results demonstrate AgNP-mediated cytotoxicity at higher concentrations. Therefore, a therapeutical window for the application of AgNP in medical products might exist."

According to the news editors, the research concluded: "However, the antibacterial benefits and potential health risks of AgNP need to be weighed in further studies."

For more information on this research see: Biocompatibility of silver nanoparticles and silver ions in primary human mesenchymal stem cells and osteoblasts. Acta Biomaterialia, 2014;10(1):439-49. (Elsevier -; Acta Biomaterialia -

The news correspondents report that additional information may be obtained from L. Pauksch, Laboratory for Experimental Trauma Surgery, Justus-Liebig University Giessen, Schubertstrasse 81, 35392 Giessen, Germany. Additional authors for this research include S. Hartmann, M. Rohnke, G. Szalay, V. Alt, R. Schnettler and K.S Lips (see also Stem Cell Research).

Keywords for this news article include: Antibacterial, Antibiotics, Antimicrobials, Europe, Giessen, Germany, Osteoblasts, Nanoparticle, Therapeutics, Nanotechnology, Stem Cell Research, Emerging Technologies, Mesenchymal Stem Cells, Connective Tissue Cells.

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Source: Drug Week

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