By a News Reporter-Staff News Editor at Clinical Trials Week -- Data detailed on Stem Cell Research have been presented. According to news originating from Xi'an, People's Republic of China, by NewsRx correspondents, research stated, "Stem cells have received a great deal of interest from the research community as potential therapeutic 'tools' for a variety of chronic debilitating diseases that lack clinically effective therapies. Stem cells are also of interest for the regeneration of tooth-supporting tissues that have been lost to periodontal disease."
Our news journalists obtained a quote from the research from Fourth Military Medical University, "Indeed, substantial data have demonstrated that the exogenous administration of stem cells or their derivatives in preclinical animal models of periodontal defects can restore damaged tissues to their original form and function. As we discuss here, however, considerable hurdles must be overcome before these findings can be responsibly translated to novel clinical therapies. Generally, the application of stem cells for periodontal therapy in clinics will not be realized until the best cell(s) to use, the optimal dose, and an effective mode of administration are identified. In particular, we need to better understand the mechanisms of action of stem cells after transplantation in the periodontium and to learn how to preciously control stem cell fates in the pathological environment around a tooth. From a translational perspective, we outline the challenges that may vary across preclinical models for the evaluation of stem cell therapy in situations that require periodontal reconstruction and the safety issues that are related to clinical applications of human stem cells."
According to the news editors, the research concluded: "Although clinical trials that use autologous periodontal ligament stem cells have been approved and have already been initiated, proper consideration of the technical, safety, and regulatory concerns may facilitate, rather than inhibit, the clinical translation of new therapies."
For more information on this research see: Translational research and therapeutic applications of stem cell transplantation in periodontal regenerative medicine. Cell Transplantation, 2013;22(2):205-29 (see also Stem Cell Research).
The news correspondents report that additional information may be obtained from H. Lu, Dept. of Periodontology and Oral Medicine, School of Stomatology, Fourth Military Medical University, Xi'an 710032, People's Taiwan. Additional authors for this research include C. Xie, Y.M. Zhao and F.M Chen.
Keywords for this news article include: Asia, Biomedical Engineering, Biomedicine, Xi'an, Surgery, Therapeutics, Bioengineering, Stem Cell Research, Cell Transplantation, Regenerative Medicine, People's Republic of China, Clinical Trials and Studies.
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