By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Researchers detail new data in Neurology. According to news reporting originating from Nashville, Tennessee, by NewsRx correspondents, research stated, "Infrared neural stimulation (INS) is an alternative neurostimulation modality that uses pulsed infrared light to evoke spatially precise neural activity that does not require direct contact with neural tissue. With these advantages INS has the potential to increase our understanding of specific neural pathways and impact current diagnostic and therapeutic clinical applications."
Our news editors obtained a quote from the research from Vanderbilt University, "In order to develop this technique, we investigate the feasibility of INS (lambda = 1.875 mu m, fiber diameter = 100-400 mu m) to activate and modulate neural activity in primary visual cortex (V1) of Macaque monkeys. Infrared neural stimulation was found to evoke localized neural responses as evidenced by both electrophysiology and intrinsic signal optical imaging (OIS). Single unit recordings acquired during INS indicated statistically significant increases in neuron firing rates that demonstrate INS evoked excitatory neural activity. Consistent with this, INS stimulation led to focal intensity-dependent reflectance changes recorded with OIS. We also asked whether INS is capable of stimulating functionally specific domains in visual cortex and of modulating visually evoked activity in visual cortex. We found that application of INS via 100 mu m or 200 mu m fiber optics produced enhancement of visually evoked OIS response confined to the eye column where INS was applied and relative suppression of the other eye column. Stimulating the cortex with a 400 mu m fiber, exceeding the ocular dominance width, led to relative suppression, consistent with involvement of inhibitory surrounds. This study is the first to demonstrate that INS can be used to either enhance or diminish visual cortical response and that this can be done in a functional domain specific manner."
According to the news editors, the research concluded: "INS thus holds great potential for use as a safe, non-contact, focally specific brain stimulation technology in primate brains."
For more information on this research see: Infrared neural stimulation of primary visual cortex in non-human primates. Neuroimage, 2014;84():181-190. Neuroimage can be contacted at: Academic Press Inc Elsevier Science, 525 B St, Ste 1900, San Diego, CA 92101-4495, USA. (Elsevier - www.elsevier.com; Neuroimage - www.elsevier.com/wps/product/cws_home/622925)
The news editors report that additional information may be obtained by contacting J.M. Cayce, Vanderbilt University, Dept. of Neurosurg, Nashville, TN 37203, United States. Additional authors for this research include R.M. Friedman, G. Chen, E.D. Jansen, A. Mahadevan-Jansen and A.W. Roe (see also Neurology).
Keywords for this news article include: Nashville, Tennessee, Neurology, United States, North and Central America
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