By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Oncology. According to news originating from Takatsuki, Japan, by NewsRx correspondents, research stated, "To analyze an intrafractional organ motion for patients with prostate cancer using soft tissue matching by megavolt computed tomography (MVCT) images during the course of image-guided intensity-modulated radiotherapy (IGRT-IMRT) using helical tomotherapy. Data from a total of 10 patients with prostate cancer who received IGRT-IMRT were analyzed, and MVCT images were acquired before and after radiation therapy."
Our news journalists obtained a quote from the research from Osaka Medical College, "Intrafractional movement and PTV margins for soft tissue matching were calculated by comparing treatment planning images with 740 MVCT images for right-left (RL), superior-inferior (SI), and anteroposterior (AP) dimensions. A total of 74 Gy/37 fractions were administered. A margin to compensate for these variations was calculated using the van Herk's equation. The intrafractional motion was 0.03 (-1.3 to 1.4) +/- 0.39 mm in the RL dimension, 0.08 (-1.8 to 0.28) +/- 0.73 mm in the SI dimension, and 0.52 (-1.8 to 1.8) +/- 0.63 mm in the AP dimension. The required PTV margin was 0.60 mm, 1.10 mm, and 0.78 mm in the RL, SI, and AP dimensions, respectively. Only one patient exhibited a deviation greater than 5 mm only once in 37 fractions (1/370=0.2%) caused by anal contraction."
According to the news editors, the research concluded: "The PTV margin in soft tissue matching IGRT-IMRT by helical tomotherapy for a patient with prostate cancer was 3 mm or less, and our tentative PTV margin of 3-5 mm is sufficient for most patients, if adequate instruction for avoiding anal contraction is given."
For more information on this research see: Analysis of Intrafractional Organ Motion for Patients with Prostate Cancer Using Soft Tissue Matching Image-guided Intensity-modulated Radiation Therapy by Helical Tomotherapy. Anticancer Research, 2013;33(12):5675-5679. Anticancer Research can be contacted at: Int Inst Anticancer Research, Editorial Office 1ST Km Kapandritiou-Kalamou Rd Kapandriti, PO Box 22, Athens 19014, Greece. (International Institute of Anticancer Research - www.iiar-anticancer.org/; Anticancer Research - www.iiar-anticancer.org/main.php?id=2)
The news correspondents report that additional information may be obtained from K. Iwama, Osaka Medical College, Dept. of Radiol, Takatsuki, Osaka 569, Japan. Additional authors for this research include H. Yamazaki, T. Nishimura, Y. Oota, H. Aibe, S. Nakamura, H. Ikeno, K. Yoshida and H. Okabe (see also Oncology).
Keywords for this news article include: Asia, Japan, Oncology, Takatsuki, Prostate Cancer, Radiation Therapy, Prostatic Neoplasms, Conformal Radiotherapy, Intensity-Modulated Radiotherapy
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