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Reports from University of Leeds Add New Data to Findings in Clinical Trials and Studies

January 29, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Clinical Research are discussed in a new report. According to news reporting originating from Leeds, United Kingdom, by NewsRx correspondents, research stated, "The ability to treat osteochondral defects is a major clinical need. Existing polymer systems cannot address the simultaneous requirements of regenerating bone and cartilage tissues together."

Our news editors obtained a quote from the research from the University of Leeds, "The challenge still lies on how to improve the integration of newly formed tissue with the surrounding tissues and the cartilage-bone interface. This study investigated the potential use of different silk fibroin scaffolds: mulberry (Bombyx mori) and non-mulberry (Antheraea mylitta) for osteochondral regeneration in vitro and in vivo. After 4 to 8 weeks of in vitro culture in chondro-or osteo-inductive media, non-mulberry constructs pre-seeded with human bone marrow stromal cells exhibited prominent areas of the neo tissue containing chondrocyte-like cells, whereas mulberry constructs pre-seeded with human bone marrow stromal cells formed bone-like nodules. In vivo investigation demonstrated neo-osteochondral tissue formed on cell-free multi-layer silk scaffolds absorbed with transforming growth factor beta 3 or recombinant human bone morphogenetic protein-2. Good bio-integration was observed between native and neo-tissue within the osteochondrol defect in patellar grooves of Wistar rats. The in vivo neo-matrix formed comprised of a mixture of collagen and glycosaminoglycans except in mulberry silk without growth factors, where a predominantly collagenous matrix was observed. Immunohistochemical assay showed stronger staining of type I and type II collagen in the constructs of mulberry and non-mulberry scaffolds with growth factors."

According to the news editors, the research concluded: "The study opens up a new avenue of using inter-species silk fibroin blended or multi-layered scaffolds of a combination of mulberry and non-mulberry origin for the regeneration of osteochondral defects."

For more information on this research see: Osteochondral tissue engineering in vivo: a comparative study using layered silk fibroin scaffolds from mulberry and nonmulberry silkworms. Plos One, 2013;8(11):e80004. (Public Library of Science -; Plos One -

The news editors report that additional information may be obtained by contacting S. Saha, Biomaterials and Tissue Engineering Group, School of Dentistry, University of Leeds, Leeds, UK. Additional authors for this research include B. Kundu, J. Kirkham, D. Wood, S.C. Kundu and X.B Yang (see also Clinical Research).

Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Leeds, Europe, Bone Research, United Kingdom, Bioengineering, Clinical Research, Clinical Trials and Studies.

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Source: Biotech Week

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