News Column

Patent Issued for Biologics Delivery System

January 30, 2014



By a News Reporter-Staff News Editor at Gene Therapy Weekly -- According to news reporting originating from Alexandria, Virginia, by NewsRx journalists, a patent by the inventors Walker, Brandon T. (Layton, UT); Marietta, Joseph Q. (Hyde Park, UT); Gerbec, Daniel E. (Logan, UT); Lorang, Douglas M. (North Logan, UT); Linville, Harold (Tipp City, OH), filed on March 7, 2011, was published online on January 14, 2014 (see also IMDS Corporation).

The assignee for this patent, patent number 8628536, is IMDS Corporation (Providence, UT).

Reporters obtained the following quote from the background information supplied by the inventors: "Biological materials, or biologies, are used extensively in surgical situations to improve patient outcomes. Biologies are therapeutic agents that are derived from living organisms. Some examples of biologies include vaccines, blood and blood components, allergenics, somatic cells, stem cells, gene therapy, tissues, and recombinant therapeutic proteins created by biological processes. The physical properties of biologic materials, as well as some other therapeutic agents, make their delivery to a surgical site difficult, especially with a minimally invasive approach.

"Most biologies delivery systems include a 'caulking gun' style delivery unit. These units are capable of delivering material in a straight line-of-sight fashion. Furthermore, most delivery systems leave wasted material within the delivery system, such as within a nozzle or tip of the delivery system.

"There is a need for a biologies delivery system that accepts a variety of biological materials. There is also a need for a biologies delivery system that is adapted for minimally invasive procedures. There is also a need for a biologies delivery system that is capable of delivering material to a surgical site via a curved path. The system also maximizes the delivered quantity of biological material, in other words, minimizing waste."

In addition to obtaining background information on this patent, NewsRx editors also obtained the inventors' summary information for this patent: "The present disclosure sets forth various embodiments of biologies delivery systems. The following is a partial list of some embodiments that fall within the scope of the present disclosure.

"An embodiment of a system for delivering a biological material to a treatment site may include a chamber for containing the biological material, and a delivery apparatus for transferring the biological material from the chamber to the treatment site. The delivery apparatus may include a housing, an outer plunger extending through the housing, and a pawl. The pawl may include a tooth portion and a tab portion. The tab portion may extend outside the housing beside the outer plunger. The delivery apparatus may have a first configuration in which the tooth portion is biased toward the outer plunger, and a second configuration in which the tab portion is urged toward alignment with the outer plunger to temporarily overcome the bias.

"In another embodiment, the delivery apparatus may transfer substantially all of the biological material from the chamber to the host site.

"In yet another embodiment, the delivery apparatus may include an inner plunger that slides within the outer plunger. The delivery apparatus may have a third configuration in which the tooth portion is biased toward the inner plunger, and a fourth configuration in which the tab portion is urged toward alignment with the inner plunger to temporarily overcome the bias.

"In yet another embodiment, the chamber may include a compartment for containing the biological material, and a tube extending from the compartment. The outer plunger may slide within the compartment and the inner plunger may slide within the tube.

"In yet another embodiment, the tube and the inner plunger may have a fixed radius of curvature.

"In yet another embodiment, the tube and the inner plunger may have a variable radius of curvature

"In yet another embodiment, when the outer plunger slides within the compartment, substantially all of the biological material may be transferred from the compartment to the tube, and when the inner plunger slides within the tube, substantially all of the biological material may be transferred from the tube to the host site.

"In yet another embodiment of a system for delivering a biological material to a host site, the system may include a compartment for containing the biological material, a tube extending from the compartment along a curved path, and a delivery apparatus for transferring the biological material from the compartment through the tube along the curved path to the host site, The delivery apparatus may include an inner plunger that slides within the tube along the curved path.

"In yet another embodiment, the delivery apparatus may transfer substantially all of the biological material from the compartment to the host site.

"In yet another embodiment, the tube and the inner plunger may have a fixed radius of curvature.

"In yet another embodiment, the tube and the inner plunger may be flexible.

"In yet another embodiment, the delivery apparatus may include an inner plunger shield covering a first end of the inner plunger. The inner plunger shield may slide within the tube ahead of the inner plunger.

"In yet another embodiment, the delivery apparatus may include an outer plunger that slides within the compartment. The inner plunger may slide within the outer plunger.

"In yet another embodiment, the delivery apparatus may include an outer plunger shield covering a first end of the outer plunger. The outer plunger shield may slide within the compartment ahead of the outer plunger.

"In yet another embodiment, the compartment may extend along the curved path. The outer plunger may slide within the compartment along the curved path.

"An embodiment of a method of delivering a biological material to a host site may include providing a delivery instrument, where the delivery instrument may include a compartment and a tube extending from the compartment along a curved path and terminating in an open tip; placing the biological material in the compartment; positioning the open tip of the tube at the host site; transferring substantially all of the biological material from the chamber through the tube along the curved path to the host site; and withdrawing the open tip of the tube from the host site.

"In another embodiment, the delivery instrument may include an outer plunger that slides within the compartment and an inner plunger that slides within the outer plunger and the tube. Transferring substantially all of the biological material from the chamber to the host site may include sliding the outer plunger within the compartment to transfer substantially all of the biological material from the compartment to the tube and sliding the inner plunger within the tube to transfer substantially all of the biological material from the tube to the host site.

"In yet another embodiment, placing the biological material in the compartment may include inserting a packet containing the biological material into the compartment.

"In yet another embodiment, the packet may include a plurality of separate chambers, where each chamber may contain a different component of the biological material.

"In yet another embodiment, the method may include sealing the biological material in the packet before inserting the packet into the compartment.

"In yet another embodiment, the method may include breaching the sealed packet before transferring substantially all of the biological material from the chamber through the tube along the curved path to the host site."

For more information, see this patent: Walker, Brandon T.; Marietta, Joseph Q.; Gerbec, Daniel E.; Lorang, Douglas M.; Linville, Harold. Biologics Delivery System. U.S. Patent Number 8628536, filed March 7, 2011, and published online on January 14, 2014. Patent URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&p=68&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=3382&f=G&l=50&co1=AND&d=PTXT&s1=20140114.PD.&OS=ISD/20140114&RS=ISD/20140114

Keywords for this news article include: Biotechnology, Treatment, Biologicals, Gene Therapy, Bioengineering, IMDS Corporation.

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Source: Gene Therapy Weekly


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