By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators publish new report on Rheumatology. According to news originating from Durham, North Carolina, by NewsRx correspondents, research stated, "Diarthrodial joints are well suited to intra-articular injection, and the local delivery of therapeutics in this fashion brings several potential advantages to the treatment of a wide range of arthropathies. Possible benefits over systemic delivery include increased bioavailability, reduced systemic exposure, fewer adverse events, and lower total drug costs."
Our news journalists obtained a quote from the research from Duke University, "Nevertheless, intra-articular therapy is challenging because of the rapid egress of injected materials from the joint space; this elimination is true of both small molecules, which exit via synovial capillaries, and of macromolecules, which are cleared by the lymphatic system. In general, soluble materials have an intra-articular dwell time measured only in hours. Corticosteroids and hyaluronate preparations constitute the mainstay of FDA-approved intra-articular therapeutics. Recombinant proteins, autologous blood products and analgesics have also found clinical use via intra-articular delivery."
According to the news editors, the research concluded: "Several alternative approaches, such as local delivery of cell and gene therapy, as well as the use of microparticles, liposomes, and modified drugs, are in various stages of preclinical development."
For more information on this research see: Progress in intra-articular therapy. Nature Reviews Rheumatology, 2014;10(1):11-22. Nature Reviews Rheumatology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group - www.nature.com/; Nature Reviews Rheumatology - www.nature.com/nrrheum/)
The news correspondents report that additional information may be obtained from C.H. Evans, Duke University, Dept. of Biomed Engn, Durham, NC 27708, United States. Additional authors for this research include V.B. Kraus and L.A. Setton (see also Rheumatology).
Keywords for this news article include: Biotechnology, Durham, Gene Therapy, Rheumatology, United States, North Carolina, Bioengineering, Adverse Drug Reaction, North and Central America
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