By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on Autoimmune Diseases and Disorders is now available. According to news reporting from Fujian, People's Republic of China, by NewsRx journalists, research stated, "Accumulative evidence demonstrates that multiple sclerosis (MS) is caused by activation of myelin Ag-reactive CD4+ T cells. Therefore, the CD4+ T cells specific for myelin Ag may be the important therapeutical target of MS."
The news correspondents obtained a quote from the research from General Hospital, "The novel coinhibitory receptor B and T lymphocyte attenuator (BTLA) may have a regulatory role in maintaining peripheral tolerance, however, its role in MS is still unknown. In this study, a novel nanoparticle containing MOG peptide with BTLA was designed and transduced into dendritic cells (DCs), and MOG peptide-induced EAE mice were adminstrated with the genetically modified DCs in vivo. The results demonstrated that modified DCs significantly enhanced the proportion of Foxp3+ CD4+ regulatory T cells, increased IL-10 and TGF-beta cytokine secretion, while decreased IL-2 and IFN-gamma cytokine secretion. Furthermore, modified DCs supressed the CD4+ T cell response to MOG, cell infiltration into spinal cord, and the severity of EAE. In contrast, immune response to irrelevant exogenous Ag was not impaired by treatment with modified DCs."
According to the news reporters, the research concluded: "These findings suggested that DCs transduced with nanoparticle could induce specific CD4+ T-cells tolerance, which provided a promising therapeutic means to negatively manipulate immune response for autoimmune diseases without inhibition of the immune response to irrelevant Ag."
For more information on this research see: A novel nanoparticle containing MUG peptide with BTLA induces T cell tolerance and prevents multiple sclerosis. Molecular Immunology, 2014;57(2):93-99. Molecular Immunology can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Molecular Immunology - www.elsevier.com/wps/product/cws_home/253)
Our news journalists report that additional information may be obtained by contacting B.Q. Yuan, Fuzhou Gen Hosp Nanjing Command, Dept. of Neurosurg, Fuzhou 350025, Fujian, People's Republic of China. Additional authors for this research include L. Zhao, F.L. Fu, Y.P. Liu, C.G. Lin, X.Q. Wu, H.C. Shen and Z. Yang (see also Autoimmune Diseases and Disorders).
Keywords for this news article include: Asia, Fujian, Genetics, Peptides, Proteins, Neurology, Proteomics, Neuroimmunology, Multiple Sclerosis, Demyelinating Diseases, People's Republic of China, Autoimmune Diseases and Disorders, CNS Demyelinating Autoimmune Diseases, Autoimmune Diseases of the Nervous System
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