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New Mononuclear Phagocyte System Study Findings Have Been Reported by Investigators at R&D Center

January 31, 2014

By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Immunology are presented in a new report. According to news reporting out of Uttar Pradesh, India, by NewsRx editors, research stated, "In this paper, we have shown that gold nanoparticles (Au (NPs)) embedded in Rubia cordifolia (RC) matrix (RC-Au (NPs)) exhibit a high therapeutic value relating to its anti-inflammatory characteristics. It was prepared by utilizing the reducing properties of RC to convert HAuCl4 into Au (NPs)."

Our news journalists obtained a quote from the research from R&D Center, "In order to compare its effectiveness, with respect to Au (NPs), the latter was synthesized separately by reducing HAuCl4 with lemon extract. These Au (NPs) along with RC-Au (NPs) were characterized by X-ray diffractometry (XRD), transmission electron microscopy (TEM), and UV-visible spectroscopy. The enhancement in anti-inflammatory characteristics was assessed as its inhibitory potential for lipopolysaccharide (LPS)-induced nitric oxide (NO) release, by rat peritoneal macrophages."

According to the news editors, the research concluded: "The RC-Au (NPs) significantly enhanced its potential to inhibit NO release, which was reported in terms of inhibitory concentration for 50% inhibition (IC50= 11.98 ng/ml), as compared to either RC extract (IC50=47 x 10(3) ng/ml) or to Au (NPs) (IC50=587.50 ng/ml)."

For more information on this research see: Enhanced antilipopolysaccharide (LPS) induced changes in macrophage functions by Rubia cordifolia (RC) embedded with Au nanoparticles. Free Radical Biology and Medicine, 2013;65():217-223. Free Radical Biology and Medicine can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Free Radical Biology and Medicine -

Our news journalists report that additional information may be obtained by contacting A.K. Singh, Prof SN Tripathi Mem Fdn, R&D Center, Varanasi 221005, Uttar Pradesh, India. Additional authors for this research include Y.B. Tripathi, N. Pandey, D.P. Singh, D. Tripathi and O.N. Srivastava (see also Immunology).

Keywords for this news article include: Asia, India, Immunology, Macrophages, Nanoparticle, Uttar Pradesh, Nanotechnology, Emerging Technologies, Mononuclear Phagocyte System

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Source: Health & Medicine Week

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