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New Findings on Catecholamines Described by Investigators at University of California

January 29, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Catecholamines have been presented. According to news reporting originating from Berkeley, California, by NewsRx correspondents, research stated, "Genetic and pharmacological studies suggest an important role of the dopamine D2 receptor (DRD2) in flexible behavioral adaptation, mostly shown in reward-based learning paradigms. Recent evidence from imaging genetics indicates that also intentional cognitive flexibility, associated with lateral frontal cortex, is affected by variations in DRD2 signaling."

Our news editors obtained a quote from the research from the University of California, "In the present functional magnetic resonance imaging (Mm) study, we tested the effects of a direct pharmacological manipulation of DRD2 stimulation on intentional flexibility in a task-switching context, requiring switches between cognitive task rules and between response hands. In a double blind, counterbalanced design, participants received either a low dose of the DRD2 agonist bromocriptine or a placebo in two separate sessions. Bromocriptine modulated the blood-oxygen-level-dependent (BOLD) signal during rule switching: rule-switching-related activity in the left posterior lateral frontal cortex and in the striatum was increased compared to placebo, at comparable performance levels. Fronto-striatal connectivity under bromocriptine was slightly increased for rule switches compared to rule repetitions. Hand-switching-related activity, in contrast, was reduced under bromocriptine in sensorimotor regions."

According to the news editors, the research concluded: "Our results provide converging evidence for an involvement of DRD2 signaling in fronto-striatal mechanisms underlying intentional flexibility, and indicate that the neural mechanisms underlying different types of flexibility (cognitive vs motor) are affected differently by increased dopaminergic stimulation."

For more information on this research see: Dissociable fronto-striatal effects of dopamine D2 receptor stimulation on cognitive versus motor flexibility. Cortex, 2013;49(10):2799-2811. Cortex can be contacted at: Elsevier Masson, Via Paleocapa 7, 20121 Milano, Italy. (Elsevier -; Cortex -

The news editors report that additional information may be obtained by contacting C. Stelzel, University of California, Dept. of Psychol, Berkeley, CA 94720, United States. Additional authors for this research include C.J. Fiebach, R. Cools, S. Tafazoli and M. D'Esposito (see also Catecholamines).

Keywords for this news article include: Pharmaceuticals, Drugs, Therapy, Berkeley, California, United States, Catecholamines, Biogenic Amines, Membrane Proteins, Organic Chemicals, Dopamine Receptors, Dopamine D2 Receptors, Dopamine Hydrochloride, North and Central America

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Source: Biotech Week

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