By a News Reporter-Staff News Editor at Health & Medicine Week -- A new study on Proteins is now available. According to news reporting originating in Gainesville, Florida, by NewsRx journalists, research stated, "Mineralized collagen composites are of interest because they have the potential to provide a bone-like scaffold that stimulates the natural processes of resorption and remodeling. Working towards this goal, our group has previously shown that the nanostructure of bone can be reproduced using a polymer-induced liquid-precursor (PILP) process, which enables intrafibrillar mineralization of collagen with hydroxyapatite to be achieved."
The news reporters obtained a quote from the research from the University of Florida, "This prior work used polyaspartic acid (pASP), a simple mimic for acidic non-collagenous proteins, to generate nanodroplets/nanoparticles of an amorphous mineral precursor which can infiltrate the interstices of type-I collagen fibrils. In this study we show that osteopontin (OPN) can similarly serve as a process-directing agent for the intrafibrillar mineralization of collagen, even though OPN is generally considered a mineralization inhibitor. We also found that inclusion of OPN in the mineralization process promotes the interaction of mouse marrow-derived osteoclasts with PILP-remineralized bone that was previously demineralized, as measured by actin ring formation. While osteoclast activation occurred when pASP was used as the process-directing agent, using OPN resulted in a dramatic effect on osteoclast activation, presumably because of the inherent arginine-glycine-aspartate acid ligands of OPN."
According to the news reporters, the research concluded: "By capitalizing on the multifunctionality of OPN, these studies may lead the way to producing biomimetic bone substitutes with the capability of tailorable bioresorption rates."
For more information on this research see: Multifunctional role of osteopontin in directing intrafibrillar mineralization of collagen and activation of osteoclasts. Acta Biomaterialia, 2014;10(1):494-507. (Elsevier - www.elsevier.com; Acta Biomaterialia - www.elsevier.com/wps/product/cws_home/702994)
Our news correspondents report that additional information may be obtained by contacting D.E. Rodriguez, Dept. of Materials Science & Engineering, University of Florida, Gainesville, FL 32611-6400, United States. Additional authors for this research include T. Thula-Mata, E.J. Toro, Y.W. Yeh, C. Holt, L.S. Holliday and L.B Gower (see also Proteins).
Keywords for this news article include: Florida, Collagen, Cytokines, Gainesville, Osteopontin, United States, Bone Research, North and Central America, Extracellular Matrix Proteins.
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