By a News Reporter-Staff News Editor at Clinical Trials Week -- New research on Clinical Research is the subject of a report. According to news reporting from Iksan, South Korea, by NewsRx journalists, research stated, "ELR-containing peptides targeting CXCR2 could be the excellent candidate for targeting ligand of molecular tumor imaging. In this study, we had developed two ELR-containing 6-mer peptides and evaluated the diagnostic performance of Tc-99m labeled 6-mer peptides as a molecular imaging agent in murine models bearing KB epidermoid carcinoma."
The news correspondents obtained a quote from the research from Wonkwang University, "Peptides were synthesized using Fmoc solid phase peptide synthesis. Radiolabeling efficiency with Tc-99m was evaluated using instant thin-layer chromatography. In KB epidermoid cancer-bearing mice, gamma images had acquired and tumor-to-muscle uptake ratio was calculated. Competition and biodistribution studies had performed. Two 6-mer peptides, ELR-ECG and ECG-ELR were successfully synthesized. After radiolabeling procedures with Tc-99m, the complex Tc-99m ELR-ECG and Tc-99m ECG-ELR were prepared in high yield. In the gamma camera imaging of murine model, Tc-99m ELR-ECG was substantially accumulated in the subcutaneously engrafted tumor and tumor uptake had been suppressed by the free ELR co-injection. However, Tc-99m ECG-ELR was minimally accumulated in the tumor. Two ELR-containing 6-mer peptides, ELR-ECG and ECG-ELR, were developed as a molecular imaging agent to target CXCR2 of epidermoid carcinoma."
According to the news reporters, the research concluded: "Tc-99m ELR-ECG had showed significant uptake in tumor and it was good candidate for a tumor imaging."
For more information on this research see: Novel Tc-99m labeled ELR-containing 6-mer peptides for tumor imaging in epidermoid carcinoma xenografts model: a pilot study. Annals of Nuclear Medicine, 2013;27(10):892-897. Annals of Nuclear Medicine can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Annals of Nuclear Medicine - www.springerlink.com/content/0914-7187/)
Our news journalists report that additional information may be obtained by contacting D.W. Kim, Wonkwang Univ, Sch Med, RUMIA, Iksan 570711, Jeollabuk Do, South Korea. Additional authors for this research include W.H. Kim, M.H. Kim and C.G. Kim (see also Clinical Research).
Keywords for this news article include: Asia, Iksan, Oncology, Peptides, Proteins, Proteomics, South Korea, Amino Acids, Nanotechnology, Clinical Research, Molecular Imaging, Epidermal Carcinoma, Emerging Technologies, Clinical Trials and Studies
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