By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Dentistry. According to news reporting out of Sao Paulo, Brazil, by NewsRx editors, research stated, "The biomodification of dentin is a biomimetic approach, mediated by bioactive agents, to enhance and reinforce the dentin by locally altering the biochemistry and biomechanical properties. This review provides an overview of key dentin matrix components, targeting effects of biomodification strategies, the chemistry of renewable natural sources, and current research on their potential clinical applications."
Our news journalists obtained a quote from the research from the University of Sao Paulo, "The PubMed database and collected literature were used as a resource for peer-reviewed articles to highlight the topics of dentin hierarchical structure, biomodification agents, and laboratorial investigations of their clinical applications. In addition, new data is presented on laboratorial methods for the standardization of proanthocyanidin-rich preparations as a renewable source of plant-derived biomodification agents. Biomodification agents can be categorized as physical methods and chemical agents. Synthetic and naturally occurring chemical strategies present distinctive mechanism of interaction with the tissue. Initially thought to be driven only by inter- or intra-molecular collagen induced non-enzymatic cross-linking, multiple interactions with other dentin components are fundamental for the long-term biomechanics and biostability of the tissue. Oligomeric proanthocyanidins show promising bioactivity, and their chemical complexity requires systematic evaluation of the active compounds to produce a fully standardized intervention material from renewable resource, prior to their detailed clinical evaluation."
According to the news editors, the research concluded: "Understanding the hierarchical structure of dentin and the targeting effect of the bioactive compounds will establish their use in both dentin-biomaterials interface and caries management."
For more information on this research see: Dentin biomodification: strategies, renewable resources and clinical applications. Dental Materials, 2014;30(1):62-76. Dental Materials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Dental Materials - www.elsevier.com/wps/product/cws_home/601024)
Our news journalists report that additional information may be obtained by contacting A.K. Bedran-Russo, University of Sao Paulo, Sch Dental, Dept. of Biochem & Dental Biomat, Sao Paulo, Brazil. Additional authors for this research include G.F. Pauli, S.N. Chen, J. McAlpine, C.S. Castellan, R.S. Phansalkar, T.R. Aguiar, C.M.P. Vidal, J.G. Napotilano, J.W. Nam and A.A. Leme (see also Dentistry).
Keywords for this news article include: Biomedical and Dental Materials, Brazil, Sao Paulo, Dentistry, South America
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