By a News Reporter-Staff News Editor at Biotech Week -- A new study on Drugs and Therapies is now available. According to news reporting originating from London, United Kingdom, by NewsRx correspondents, research stated, "Chemotherapy has made substantial progress in the therapy of systemic cancer, but the phar-macological efficacy is insufficient in the treatment of brain metastases. Fractionated whole brain radiotherapy (WBRT) has been a standard treatment of brain metastases, but provides limited local tumor control and often unsatisfactory clinical results."
Our news editors obtained a quote from the research from Guy's and St. Thomas' NHS Foundation Trust, "Stereotactic radiosurgery using Gamma Knife, Linac or Cyberknife has overcome several of these limitations, which has influenced recent treatment recommendations. This present review summarizes the current literature of single session radiosurgery concerning survival and quality of life, specific responses, tumor volumes and numbers, about potential treatment combinations and radioresistant metastases. Gamma Knife and Linac based radiosurgery provide consistent results with a reproducible local tumor control in both single and multiple brain metastases. Ideally minimum doses of >18 Gy are applied. Reported local control rates were 90-94% for breast cancer metastases and 81-98% for brain metastases of lung cancer. Local tumor control rates after radiosurgery of otherwise radioresistant brain metastases were 73-90% for melanoma and 83-96% for renal cell cancer. Currently, there is a tendency to treat a larger number of brain metastases in a single radiosurgical session, since numerous studies document high local tumor control after radiosurgical treatment of >3 brain metastases. New remote brain metastases are reported in 33-42% after WBRT and in 39-52% after radiosurgery, but while WBRT is generally applied only once, radiosurgery can be used repeatedly for remote recurrences or new metastases after WBRT. Larger metastases (>8-10 cc) should be removed surgically, but for smaller metastases Gamma Knife radiosurgery appears to be equally effective as surgical tumor resection (level I evidence). Radiosurgery avoids the impairments in cognition and quality of life that can be a consequence of WBRT (level I evidence)."
According to the news editors, the research concluded: "High local efficacy, preservation of cerebral functions, short hospitalization and the option to continue a systemic chemotherapy are factors in favor of a minimally invasive approach with stereotactic radiosurgery."
For more information on this research see: Stereotactic radiosurgery in the treatment of brain metastases: The current evidence. Cancer Treatment Reviews, 2014;40(1):48-59. Cancer Treatment Reviews can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Cancer Treatment Reviews - www.elsevier.com/wps/product/cws_home/623022)
The news editors report that additional information may be obtained by contacting B. Lippitz, Guys & St Thomas NHS Fdn Trust, London, United Kingdom. Additional authors for this research include C. Lindquist, I. Paddick, D. Peterson, K. O'Neill and R. Beaney (see also Drugs and Therapies).
Keywords for this news article include: London, Europe, Cancer, Oncology, Treatment, Chemotherapy, Radiotherapy, United Kingdom, Drugs and Therapies
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