News Column

Findings on Cancer Gene Therapy Reported by Researchers at Kyungpook National University

January 27, 2014

By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting originating in Daegu, South Korea, by NewsRx journalists, research stated, "Hypoxia-inducible factors (HIFs) are master regulators of angiogenesis and cellular adaptation in hypoxic microenvironments. Accumulating evidence indicates that HIFs also regulate cell survival, glucose metabolism, microenvironmental remodeling, cancer metastasis, and tumor progression, and thus, HIFs are viewed as therapeutic targets in many diseases."

The news reporters obtained a quote from the research from Kyungpook National University, "Epigenetic changes are involved in the switching 'on' and 'off' of many genes, and it has been suggested that the DNA hypermethylation of specific gene promoters, histone modifications (acetylation, phosphorylation, and methylation) and small interfering or micro RNAs be regarded epigenetic gene targets for the regulation of disease-associated cellular changes. Furthermore, the hypoxic microenvironment is one of the most important cellular stress stimuli in terms of the regulation of cellular epigenetic status via histone modification. Therefore, drug development and therapeutic approaches to ischemic diseases or cancer for targeting HIFs by modulation of epigenetic status become an attractive area."

According to the news reporters, the research concluded: "Here, the authors provide a review of the literature regarding the targeting of HIF, a key modulator of hypoxic-cell response under various disease conditions, by modulating histone or DNA using endogenous small RNAs or exogenous chemicals."

For more information on this research see: Epigenetic regulation of hypoxia inducible factor in diseases and therapeutics. Archives of Pharmacal Research, 2013;36(3):252-63. Archives of Pharmacal Research can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer -; Archives of Pharmacal Research -

Our news correspondents report that additional information may be obtained by contacting M.P. Nguyen, School of Life Sciences and Biotechnology, College of Pharmacy, Kyungpook National University, Daegu, 702-701, South Korea. Additional authors for this research include S. Lee and Y.M Lee (see also Biotechnology).

The publisher of the journal Archives of Pharmacal Research can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Asia, Biotechnology, Daegu, Genetics, South Korea, Cancer Gene Therapy.

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Source: Cancer Gene Therapy Week

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