By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Drugs and Therapies. According to news reporting originating in Richmond, Virginia, by NewsRx journalists, research stated, "To analyze primary tumor (PT) and lymph node (LN) position changes relative to each other and relative to anatomic landmarks during conventionally fractionated radiation therapy for patients with locally advanced lung cancer. In 12 patients with locally advanced non-small cell lung cancer PT, LN, carina, and 1 thoracic vertebra were manually contoured on weekly 4-dimensional fan-beam CT scans."
The news reporters obtained a quote from the research from Virginia Commonwealth University, "Systematic and random interfraction displacements of all contoured structures were identified in the 3 cardinal directions, and resulting setup margins were calculated. Time trends and the effect of volume changes on displacements were analyzed. Three-dimensional displacement vectors and systematic/random interfraction displacements were smaller for carina than for vertebra both for PT and LN. For PT, mean (SD) 3-dimensional displacement vectors with carina-based alignment were 7 (4) mm versus 9 (5) mm with bony anatomy (P <.0001). For LN, smaller displacements were found with carina-(5  mm, P<.0001) and vertebra-based (6  mm, P = .002) alignment compared with using PT for setup (8  mm). Primary tumor and LN displacements relative to bone and carina were independent (P >.05). Displacements between PT and bone (P = .04) and between PT and LN (P = .01) were significantly correlated with PT volume regression. Displacements between LN and carina were correlated with LN volume change (P = .03). Carina-based setup results in a more reproducible PT and LN alignment than bony anatomy setup."
According to the news reporters, the research concluded: "Considering the independence of PT and LN displacement and the impact of volume regression on displacements over time, repeated CT imaging even with PT-based alignment is recommended in locally advanced disease."
For more information on this research see: Interfraction Displacement of Primary Tumor and Involved Lymph Nodes Relative to Anatomic Landmarks in Image Guided Radiation Therapy of Locally Advanced Lung Cancer. International Journal of Radiation Oncology Biology Physics, 2014;88(1):210-215. International Journal of Radiation Oncology Biology Physics can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA (see also Drugs and Therapies).
Our news correspondents report that additional information may be obtained by contacting N. Jan, Virginia Commonwealth University, Dept. of Biostat, Richmond, VA 23298, United States. Additional authors for this research include S. Balik, G.D. Hugo, N. Mukhopadhyay and E. Weiss.
Keywords for this news article include: Richmond, Virginia, Oncology, Lung Cancer, Lymph Nodes, United States, Lung Neoplasms, Radiation Therapy, Drugs and Therapies, Hemic and Immune Systems, North and Central America
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