By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Bone Research. According to news reporting from Tehran, Iran, by NewsRx journalists, research stated, "A combination of bioceramics and osteogenic factors is potentially useful for bone regeneration applications. In the present study, hydroxyapatite particles (HA) were loaded with dexamethasone (Dex) and then characterized using SEM and drug release study."
The news correspondents obtained a quote from the research from the Shaheed Beheshti University of Medical Sciences, "The bone regeneration ability of Dex-loaded HA (Dex/HA) was investigated in a rat critical size bone defect using digital mammography, multislice spiral-computed tomography (MSCT) imaging, and histological analysis. The HA and Dex/HA showed nano and micro-scale morphology with a nearly homogenous distribution of diameter. In addition, about 90 % of the drug was released from Dex/HA over a period of three days. After 8 weeks of implantation in rat calvarial defects, no sign of inflammation or complication was observed at the site of surgery. According to digital mammography and MSCT, Dex/HA showed the highest bone regeneration in rat bone defects compared to those received drug-free HA. Histological studies confirmed these data and showed osteointegration to the surrounding tissue. Taking all together, it was demonstrated that Dex/HA can be used as an appropriate synthetic graft for bone tissue engineering applications."
According to the news reporters, the research concluded: "These newly developed bioceramics can be used as new bone graft substitutes in orthopaedic surgery and is capable of enhancing bone regeneration."
For more information on this research see: Dexamethasone-loaded hydroxyapatite enhances bone regeneration in rat calvarial defects. Molecular Biology Reports, 2014;41(1):423-428. Molecular Biology Reports can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Molecular Biology Reports - www.springerlink.com/content/0301-4851/)
Our news journalists report that additional information may be obtained by contacting R. Tavakoli-darestani, Shahid Beheshti Univ Med Sci, Dept. of Orthoped Surg, Fac Med, Tehran, Iran. Additional authors for this research include A. Manafi-rasi and A. Kamrani-rad (see also Bone Research).
Keywords for this news article include: Iran, Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Pharmaceuticals, Drugs, Tehran, Surgery, Therapy, Hormones, Phosphates, Bone Research, Dexamethasone, Bioengineering, Topical Agents, Glucocorticoids, Hydroxyapatites, Phosphoric Acids, Ophthalmic Steroids, Ophthalmic Preparations
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