By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting originating in Kumamoto, Japan, by NewsRx journalists, research stated, "Ultrasound (US) is used in the clinical setting not only for diagnosis but also for therapy. As a therapeutic US technique, high-intensity focused ultrasound (HIFU) can be applied to treat cancer in a clinical setting."
The news reporters obtained a quote from the research from Graduate School, "Microbubbles increased temperature and improved the low therapeutic efficiency under HIFU; however, microbubbles have room for improvement in size, stability, and targeting ability. To solve these issues, we reported that 'Bubble liposomes' (BLs) containing the US imaging gas (perfluoropropane gas) liposomes were suitable for ultrasound imaging and gene delivery. In this study, we examined whether BLs and HIFU could enhance the ablation area of the tumor and the antitumor effect. First, we histologically analyzed the tumor after BLs and HIFU. The ablation area of the treatment of BLs and HIFU was broader than that of HIFU alone. Next, we monitored the temperature of the tumor, and examined the antitumor effect. The temperature increase with BLs and HIFU treatment was faster and higher than that with HIFU alone. Moreover, treatment with BLs and HIFU enhanced the antitumor effect, which was better than with HIFU alone."
According to the news reporters, the research concluded: "Thus, the combination of BLs and HIFU could be efficacious for cancer therapy."
For more information on this research see: Combination of Bubble Liposomes and High-Intensity Focused Ultrasound (HIFU) Enhanced Antitumor Effect by Tumor Ablation. Biological & Pharmaceutical Bulletin, 2014;37(1):174-177. Biological & Pharmaceutical Bulletin can be contacted at: Pharmaceutical Soc Japan, 2-12-15Shibuya, Shibuya-Ku, Tokyo, 150-0002, Japan (see also technology.html">Biotechnology).
Our news correspondents report that additional information may be obtained by contacting N. Hamano, Grad Sch Sci & Technol, Dept. of Appl Chem & Biochem, Chuo Ku, Kumamoto 8608555, Japan. Additional authors for this research include Y. Negishi, K. Takatori, Y. Endo-Takahashi, R. Suzuki, K. Maruyama, T. Niidome and Y. Aramaki.
Keywords for this news article include: Asia, Biotechnology, Japan, Surgery, Kumamoto, Liposomes, Treatment, Bioengineering, Cancer Gene Therapy, Drug Delivery Systems, Transrectal Ultrasound, High-Intensity Focused Ultrasound Ablation
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