By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Mononuclear Leukocytes have been presented. According to news originating from Lisbon, Portugal, by NewsRx correspondents, research stated, "Toxicological characterization of manufactured nanomaterials (NMs) is essential for safety assessment, while keeping pace with innovation from their development and application in consumer products. The specific physicochemical properties of NMs, including size and morphology, might influence their toxicity and have impact on human health."
Our news journalists obtained a quote from the research from the National Institutes of Health, "The present work aimed to evaluate the genotoxicity of nanosized titanium dioxide (TiO2), synthetic amorphous silica (SAS) and multiwalled carbon nanotubes (MWCNTs), in human lymphocytes. The morphology and size of those NMs were characterized by transmission electron microscopy, while the hydrodynamic particle size-distributions were determined by dynamic light scattering. Using a standardized procedure to ensure the dispersion of the NMs and the cytokinesis-block micronucleus assay (without metabolic activation), we observed significant increases in the frequencies of micronucleated binucleated cells (MNBCs) for some TiO2 NMs and for two MWCNTs, although no clear dose-response relationships could be disclosed. In contrast, all forms of SAS analyzed in this study were unable to induce micronuclei. The present findings increase the weight of evidence towards a genotoxic effect of some forms of TiO2 and some MWCNTs."
According to the news editors, the research concluded: "Regarding safety assessment, the differential genotoxicity observed for closely related NMs highlights the importance of investigating the toxic potential of each NM individually, instead of assuming a common mechanism and equal genotoxic effects for a set of similar NMs."
For more information on this research see: Genotoxicity evaluation of nanosized titanium dioxide, synthetic amorphous silica and multi-walled carbon nanotubes in human lymphocytes. Toxicology In Vitro, 2014;28(1):60-9. (Elsevier - www.elsevier.com; Toxicology In Vitro - www.elsevier.com/wps/product/cws_home/800)
The news correspondents report that additional information may be obtained from A.M. Tavares, Dept. of Human Genetics, National Institute of Health Dr Ricardo Jorge (INSA), Av Padre Cruz, 1649-016 Lisbon, Portugal. Additional authors for this research include H. Louro, S. Antunes, S. Quarre, S. Simar, P.J. De Temmerman, E. Verleysen, J. Mast, K.A. Jensen, H. Norppa, F. Nesslany and M.J Silva (see also Mononuclear Leukocytes).
Keywords for this news article include: Lisbon, Europe, Portugal, Chemicals, Chemistry, Fullerenes, Immunology, Blood Cells, Lymphocytes, Light Metals, Nanotechnology, Carbon Nanotubes, Titanium Dioxide, Emerging Technologies, Mononuclear Leukocytes, Hemic and Immune Systems.
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