By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in DNA Research. According to news reporting originating in Piscataway, New Jersey, by NewsRx journalists, research stated, "The AgrA transcription factor regulates the quorum-sensing response in Staphylococcus aureus, controlling the production of hemolysins and other virulence factors. AgrA binds to DNA via its C-terminal LytTR domain, a domain not found in humans but common in many pathogenic bacteria, making it a potential target for antimicrobial development."
The news reporters obtained a quote from the research from the University of Medicine and Dentistry of New Jersey (UMDNJ), "We have determined the crystal structure of the apo AgrA LytTR domain and screened a library of 500 fragment compounds to find inhibitors of AgrA DNA binding activity. Using nuclear magnetic resonance, the binding site for five compounds has been mapped to a common locus at the C-terminal end of the LytTR domain, a site known to be important for DNA binding activity. Three of these compounds inhibit AgrA DNA binding."
According to the news reporters, the research concluded: "These results provide the first evidence that LytTR domains can be targeted by small organic compounds."
For more information on this research see: Identification of a hydrophobic cleft in the LytTR domain of AgrA as a locus for small molecule interactions that inhibit DNA binding. Biochemistry, 2012;51(50):10035-43. Biochemistry can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (American Chemical Society - www.acs.org; Biochemistry - www.pubs.acs.org/journal/bichaw)
Our news correspondents report that additional information may be obtained by contacting P.G. Leonard, Center for Advanced Biotechnology and Medicine, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway, NJ 08854-5635, United States. Additional authors for this research include I.F. Bezar, D.J. Sidote and A.M Stock (see also DNA Research).
The publisher of the journal Biochemistry can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA.
Keywords for this news article include: Piscataway, New Jersey, DNA Research, United States, North and Central America.
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