By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting from Nottingham, United Kingdom, by NewsRx journalists, research stated, "2-(4-Amino-3-methylphenyl)-5-fluorobenzothiazole (5F203, NSC 703786) lysylamide belongs to a novel mechanistic class of antitumor agents. It elicits activity against ovarian, breast, kidney and colorectal cancer models."
The news correspondents obtained a quote from the research from the University of Nottingham, "In sensitive breast cancer cells, 5F203 activates aryl hydrocarbon receptor (AhR) signaling. Herein, we evaluate the role of AhR in 5F203 activity in two ovarian cancer cell lines: IGROV-1 (sensitive to 5F203), SKOV-3 (resistant to this agent). In addition, cancer cells have been isolated from ascites fluid of ovarian cancer patients; sensitivity to 5F203 and concurrent AhR signal transduction has been examined in ascites-isolated ovarian cancer patients' cells. 5F203 induced enhanced CYP1A1 expression, AhR translocation and ROS formation in IGROV-1 cells and ascites-isolated ovarian cancer cells that were sensitive to 5F203. In IGROV-1 cells 5F203-induced ROS formation was accompanied by JNK, ERK and P38MAPK phosphorylation, DNA damage and cell cycle arrest prior to apoptosis. In contrast, 5F203 failed to induce CYP1A1 expression, AhR translocation or oxidative stress in 5F203-resistant SKOV-3 cells, or in ovarian cancer ascites cells inherently resistant to this agent. We propose that AhR may represent a new molecular target in the treatment of ovarian tumors and 5F203 may exemplify a potential novel treatment."
According to the news reporters, the research concluded: "Furthermore, putative biomarkers of sensitivity to this agent have been identified. J. Cell. Biochem. 114: 2392-2404, 2013."
For more information on this research see: Biomarkers of Sensitivity to Potent and Selective Antitumor 2-(4-Amino-3-Methylphenyl)-5-Fluorobenzothiazole (5F203) in Ovarian Cancer. Journal of Cellular Biochemistry, 2013;114(10):2392-2404. Journal of Cellular Biochemistry can be contacted at: Wiley-Blackwell, 111 River St, Hoboken 07030-5774, NJ, USA. (Wiley-Blackwell - www.wiley.com/; Journal of Cellular Biochemistry - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1097-4644)
Our news journalists report that additional information may be obtained by contacting M.A. Callero, University of Nottingham, Center Biomol Sci, Nottingham NG7 2RD, United Kingdom. Additional authors for this research include G.A. Luzzani, D.O. De Dios, T.D. Bradshaw and A.I.L. Perez (see also technology.html">Biotechnology).
Keywords for this news article include: Biotechnology, Europe, Oncology, Treatment, Nottingham, United Kingdom, Cancer Gene Therapy
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