By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators discuss new findings in Cardiology. According to news reporting originating from Norfolk, Virginia, by NewsRx correspondents, research stated, "Much is anticipated from the development and deployment of nanomaterials in biological organisms, but concerns remain regarding their biocompatibility and target specificity. Here we report our study of the transport, biocompatibility and toxicity of purified and stable silver nanoparticles (Ag NPs, 13.1 ± 2.5 nm in diameter) upon the specific developmental stages of zebrafish embryos using single NP plasmonic spectroscopy."
Our news editors obtained a quote from the research from Old Dominion University, "We find that single Ag NPs passively diffuse into five different developmental stages of embryos (cleavage, early-gastrula, early-segmentation, late-segmentation, and hatching stages), showing stage-independent diffusion modes and diffusion coefficients. Notably, the Ag NPs induce distinctive stage and dose-dependent phenotypes and nanotoxicity, upon their acute exposure to the Ag NPs (0-0.7 nM) for only 2 h. The late-segmentation embryos are most sensitive to the NPs with the lowest critical concentration (CNP,c
According to the news editors, the research concluded: "These important findings suggest that the Ag NPs are not simple poisons, and they can target specific pathways in development, and potentially enable target specific study and therapy for early embryonic development."
For more information on this research see: Silver nanoparticles induce developmental stage-specific embryonic phenotypes in zebrafish. Nanoscale, 2013;5(23):11625-36. (Royal Society of Chemistry - www.rsc.org/; Nanoscale - pubs.rsc.org/en/journals/journalissues/nr)
The news editors report that additional information may be obtained by contacting K.J. Lee, Dept. of Chemistry, Biochemistry, Old Dominion University, Norfolk, VA 23529, United States. Additional authors for this research include L.M. Browning, P.D. Nallathamby, C.J. Osgood and X.H Xu (see also Cardiology).
Keywords for this news article include: Norfolk, Virginia, Cardiology, Nanoparticle, United States, Nanotechnology, Emerging Technologies, North and Central America.
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC