By a News Reporter-Staff News Editor at Women's Health Weekly -- New research on Oncology is the subject of a report. According to news reporting out of Athens, Georgia, by NewsRx editors, research stated, "A therapeutic technology that combines the phototoxic and immune-stimulating ability of photodynamic therapy (PDT) with the widespread effectiveness of the immune system can be very promising to treat metastatic breast cancer. We speculated that the knowledge of molecular mechanisms of existing multi-component therapies could provide clues to aid the discovery of new combinations of an immunostimulant with a photosensitizer (PS) using a nanoparticle (NP) delivery platform."
Our news journalists obtained a quote from the research from the University of Georgia, "Therapeutic challenges when administering therapeutic combinations include the choice of dosages to reduce side effects, the definitive delivery of the correct drug ratio, and exposure to the targets of interest. These factors are very difficult to achieve when drugs are individually administered. By combining controlled release polymer-based NP drug delivery approaches, we were able to differentially deliver zinc phthalocyanine (ZnPc) based PS to metastatic breast cancer cells along with CpG-ODN, a single-stranded DNA that is a known immunostimulant to manage the distant tumors in a temporally regulated manner. We encapsulated ZnPc which is a long-wavelength absorbing PS within a polymeric NP core made up of poly(d,l-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG). After coating the outside of the polymeric core with gold NPs (AuNPs), we further modified the AuNP surface with CpG-ODN. In vitro cytotoxicity using 4T1 metastatic mouse breast carcinoma cells shows significant photocytotoxicity of the hybrid NPs containing both ZnPc and CpG-ODN after irradiation with a 660 nm LASER light and this activity was remarkably better than either treatment alone."
According to the news editors, the research concluded: "Treatment of mouse bone marrow derived dendritic cells with the PDT-killed 4T1 cell lysate shows that the combination of PDT with a synergistic immunostimulant in a single NP system results in significant immune response, which can be used for the treatment of metastatic cancer."
For more information on this research see: Immune stimulating photoactive hybrid nanoparticles for metastatic breast cancer. Integrative Biology, 2013;5(1):215-23. (Royal Society of Chemistry - www.rsc.org/; Integrative Biology - pubs.rsc.org/en/journals/journalissues/ib)
Our news journalists report that additional information may be obtained by contacting S. Marrache, Nano Therapeutics Research Lab, Dept. of Chemistry, University of Georgia, Athens, GA 30602, United States. Additional authors for this research include J.H. Choi, S. Tundup, D. Zaver, D.A. Harn and S. Dhar (see also Oncology).
Keywords for this news article include: Athens, Georgia, Therapy, Oncology, Treatment, Nanoparticle, United States, Breast Cancer, Nanotechnology, Women's Health, Emerging Technologies, North and Central America.
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