By a News Reporter-Staff News Editor at Women's Health Weekly -- Fresh data on Oncology are presented in a new report. According to news originating from Chongqing, People's Republic of China, by NewsRx correspondents, research stated, "To investigate the feasibility of evaluating tumor lymphangiogenesis using magnetic resonance imaging (MRI) in vivo. Water-soluble polyethylene glycol (PEG)-GoldMag nanoparticles were obtained by combining GoldMag with PEG."
Our news journalists obtained a quote from the research from Third Military Medical University, "The PEG-GoldMag nanoparticles were bound to anti-podoplanin antibody (PodAb) to construct PEG-GoldMag-pod molecular probes targeting lymphatic endothelial cells (LECs). The characteristics of the PEG-GoldMag-pod nanoparticles were tested. Using these nanoparticles, tumor lymphangiogenesis was evaluated using MRI in vitro and in vivo. The average size of PEG-GoldMag nanoparticles was about 66.8 nm, and the nanoparticles were stably dispersed in the liquid phase for at least 15 days. After incubation for 24 h at different iron concentrations ranging from 5-45 ?g/ml, the LECs were labelled with PEG-GoldMag-pod nanoparticles, in particular the breast cancer LECs. Dose-dependence was observed in the labelling efficiencies and MRI images of the labelled cells. In vitro, the labelling efficiencies and MRI images showed that the nanoparticles could detect podoplanin expression in LECs. In induced rat models of breast cancer, PEG-GoldMag-pod nanoparticles combined with lymphatic vessels were significantly detectable at MRI 60 min after nanoparticle administration, the signal intensity was negatively correlated with the lymphatic vessel density of breast cancer (r=-0.864, p=0.000)."
According to the news editors, the research concluded: "The present study proves the feasibility of evaluating tumor lymphangiogenesis with MRI in vivo."
For more information on this research see: Feasibility of MR imaging in evaluating breast cancer lymphangiogenesis using Polyethylene glycol-GoldMag nanoparticles. Clinical Radiology, 2013;68(12):1233-40. (Elsevier - www.elsevier.com; Clinical Radiology - www.elsevier.com/wps/product/cws_home/623019)
The news correspondents report that additional information may be obtained from H. Yang, Dept. of Radiology, Xinqiao Hospital, Third Military Medical University, Chongqing, People's Taiwan. Additional authors for this research include L.G. Zou, S. Zhang, M.F. Gong, D. Zhang, Y.Y. Qi, S.W. Zhou and X.W Diao (see also Oncology).
Keywords for this news article include: Asia, Alkenes, Oncology, Polyenes, Chongqing, Immunology, Hydrocarbons, Nanoparticle, Breast Cancer, Nanotechnology, Women's Health, Lymphatic System, Lymphatic Vessels, Organic Chemicals, Polyethylene Glycols, Emerging Technologies, People's Republic of China.
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