By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on DNA Research have been published. According to news reporting from Changsha, People's Republic of China, by NewsRx journalists, research stated, "A DNA configuration switch is designed to fabricate a reversible and regenerable Raman-active substrate. The substrate is composed of a Au film and a hairpin-shaped DNA strand (hot-spot-generation probes, HSGPs) labeled with dye-functionalized silver nanoparticles (AgNPs)."
The news correspondents obtained a quote from the research from Hunan University, "Another ssDNA that recognizes a specific trigger is used as an antenna. The HSGPs are immobilized on the Au film to draw the dye-functionalized AgNPs close to the Au surface and create an intense electromagnetic field. Hybridization of HSGP with the two arm segments of the antenna forms a triplex-stem structure to separate the dye-functionalized AgNPs from the Au surface, quenching the Raman signal. Interaction with its trigger releases the antenna from the triplex-stem structure, and the hairpin structure of the HSGP is restored, creating an effective 'off-on' Raman signal switch. Nucleic acid sequences associated with the HIV-1 U5 long terminal repeat sequences and ATP are used as the triggers."
According to the news reporters, the research concluded: "The substrate shows excellent reversibility, reproducibility, and controllability of surface-enhanced Raman scattering (SERS) effects, which are significant requirements for practical SERS sensor applications."
For more information on this research see: Fabricating a reversible and regenerable Raman-active substrate with a biomolecule-controlled DNA nanomachine. Journal of the American Chemical Society, 2012;134(49):19957-60. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)
Our news journalists report that additional information may be obtained by contacting J. Zheng, Molecular Science and Biomedicine Laboratory, College of Chemistry and Chemical Engineering, College of Biology, Hunan University, Changsha, 410082, People's Taiwan. Additional authors for this research include A. Jiao, R. Yang, H. Li, J. Li, M. Shi, C. Ma, Y. Jiang, L. Deng and W. Tan (see also DNA Research).
Keywords for this news article include: Asia, Changsha, DNA Research, People's Republic of China.
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