By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Proteins are presented in a new report. According to news reporting originating in Amsterdam, Netherlands, by NewsRx journalists, research stated, "High-density lipoprotein (HDL) is a natural nanoparticle that transports peripheral cholesterol to the liver. Reconstituted high-density lipoprotein (rHDL) exhibits antiatherothrombotic properties and is being considered as a natural treatment for cardiovascular diseases."
The news reporters obtained a quote from the research from the University of Amsterdam, "Furthermore, HDL nanoparticle platforms have been created for targeted delivery of therapeutic and diagnostic agents. The current methods for HDL reconstitution involve lengthy procedures that are challenging to scale up. A central need in the synthesis of rHDL, and multifunctional nanomaterials in general, is to establish large-scale production of reproducible and homogeneous batches in a simple and efficient fashion. Here, we present a large-scale microfluidics-based manufacturing method for single-step synthesis of HDL-mimicking nanomaterials (mu HDL). mu HDL is shown to have the same properties (e.g., size, morphology, bioactivity) as conventionally reconstituted HDL and native HDL. In addition, we were able to incorporate simvastatin (a hydrophobic drug) into mu HDL, as well as gold, iron oxide, quantum dot nanocrystals or fluorophores to enable its detection by computed tomography (CT), magnetic resonance imaging (MRI), or fluorescence microscopy, respectively."
According to the news reporters, the research concluded: "Our approach may contribute to effective development and optimization of lipoprotein-based nanomaterials for medical imaging and drug delivery."
For more information on this research see: Single Step Reconstitution of Multifunctional High-Density Lipoprotein-Derived Nanomaterials Using Microfluidics. ACS Nano, 2013;7(11):9975-9983. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting Y. Kim, University of Amsterdam, Academy Med Center, Dept. of Vasc Med, NL-1105 AZ Amsterdam, Netherlands. Additional authors for this research include F. Fay, D.P. Cormode, B.L. Sanchez-Gaytan, J. Tang, E.J. Hennessy, M.M. Ma, K. Moore, O.C. Farokhzad, E.A. Fisher, W.J.M. Mulder, R. Langer and Z.A. Fayad (see also Proteins).
Keywords for this news article include: Europe, Lipids, Amsterdam, Netherlands, Lipoproteins, Nanomaterial, Nanotechnology, Emerging Technologies
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC