By a News Reporter-Staff News Editor at Science Letter -- A new study on Science is now available. According to news originating from Lausanne, Switzerland, by NewsRx correspondents, research stated, "In subunit vaccines, strong CD8(+) T-cell responses are desired, yet they are elusive at reasonable adjuvant doses. We show that targeting adjuvant to the lymph node (LN) via ultrasmall polymeric nanoparticles (NPs), which rapidly drain to the LN after intradermal injection, greatly enhances adjuvant efficacy at low doses."
Our news journalists obtained a quote from the research from the School of Basic Science, "Coupling CpG-B or CpG-C oligonucleotides to NPs led to better dual-targeting of adjuvant and antigen (codelivered on separate NPs) in cross-presenting dendritic cells compared with free adjuvant. This led to enhanced dendritic cell maturation and T helper 1 (Th1)-cytokine secretion, in turn driving stronger effector C8(+) T-cell activation with enhanced cytolytic profiles and, importantly, more powerful memory recall. With only 4 mu g CpG, NP-CpG-B could substantially protect mice from syngeneic tumor challenge, even after 4 mo of vaccination, compared with free CpG-B."
According to the news editors, the research concluded: "Together, these results show that nanocarriers can enhance vaccine efficacy at a low adjuvant dose for inducing potent and long-lived cellular immunity."
For more information on this research see: Nanoparticle conjugation of CpG enhances adjuvancy for cellular immunity and memory recall at low dose. Proceedings of the National Academy of Sciences of the United States of America, 2013;110(49):19902-19907. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)
The news correspondents report that additional information may be obtained from A. de Titta, Ecole Polytechnic Fed Lausanne, Sch Basic Sci, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland. Additional authors for this research include M. Ballester, Z. Julier, C. Nembrini, L. Jeanbart, A.J. van der Vlies, M.A. Swartz and J.A. Hubbell (see also Science).
Keywords for this news article include: Europe, Science, Lausanne, Switzerland
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