By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on DNA Research have been published. According to news originating from Santa Barbara, California, by NewsRx correspondents, research stated, "Many biological systems employ allosteric regulatory mechanisms, which offer a powerful means of directly linking a specific binding event to a wide spectrum of molecular functionalities. There is considerable interest in generating synthetic allosteric regulators that can perform useful molecular functions for applications in diagnostics, imaging and targeted therapies, but generating such molecules through either rational design or directed evolution has proven exceptionally challenging."
Our news journalists obtained a quote from the research from the University of California, "To address this need, we present an in vitro selection strategy for generating conformation-switching DNA nanostructures that selectively release a small-molecule payload in response to binding of a specific trigger molecule. As an exemplar, we have generated a DNA nanostructure that hybridizes with a separate 'cargo strand' containing an abasic site. This abasic site stably sequesters a fluorescent cargo molecule in an inactive state until the DNA nanostructure encounters an ATP trigger molecule. This ATP trigger causes the nanostructure to release the cargo strand, thereby liberating the fluorescent payload and generating a detectable fluorescent readout. Our DNA nanostructure is highly sensitive, with an EC50 of 30 mu M, and highly specific, releasing its payload in response to ATP but not to other chemically similar nucleotide triphosphates."
According to the news editors, the research concluded: "We believe that this selection approach could be generalized to generate synthetic nanostructures capable of selective and controlled release of other small-molecule cargos in response to a variety of triggers, for both research and clinical applications."
For more information on this research see: In Vitro Selection of Shape-Changing DNA Nanostructures Capable of Binding-Induced Cargo Release. ACS Nano, 2013;7(11):9675-9683. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
The news correspondents report that additional information may be obtained from S.S. Oh, University of California, Dept. of Mech Engn, Santa Barbara, CA 93106, United States. Additional authors for this research include K. Plakos, Y. Xiao, M. Eisenstein and H.T. Soh (see also DNA Research).
Keywords for this news article include: California, DNA Research, Santa Barbara, United States, Nanostructural, Nanostructures, Nanotechnology, Emerging Technologies, North and Central America
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